Allergy Asthma Respir Dis.  2015 Mar;3(2):105-108. 10.4168/aard.2015.3.2.105.

Risk factors of allergic sensitization in preschool children with chronic cough

• Lee ES
• Bang JS
• Oh YJ
• Lee JW
• Sung TJ
• Lee YJ
• Lee KH

• KMID: 2168501
• DOI: http://doi.org/10.4168/aard.2015.3.2.105

Abstract

PURPOSE
Chronic cough is one of the major symptoms of asthma and allergic sensitization and may appear prior to the onset of asthma. The object of this study was to investigate the risk of allergic sensitization in preschool children with chronic cough.
METHODS
We reviewed the medical records of 99 preschool children presenting with chronic cough but not with allergic rhinitis, atopic dermatitis, recurrent wheezing, or lower respiratory tract infection between November 2011 and July 2013.
RESULTS
Fifty-four children (55%) were sensitized at least one of the following inhalant allergens: Dermatophagoides pteronyssinus, Dermatophagoides farinae, cockroach, Alternaria alternata, dog dander, and cat epithelium. Children with allergic sensitization had a higher blood total IgE levels transformed by common logarithm (1.9+/-0.6 IU/mL vs. 1.3+/-0.5 IU/mL, P<0.001) and eosinophils (3.7%+/-2.5% vs. 2.7%+/-2.0%, P=0.043), more frequent parental history of allergy (68% vs. 48%, P=0.044) and less frequent history of breast milk feeding (68% vs. 86%, P=0.041) than those without.
CONCLUSION
These results suggest that the ratio of allergic sensitization may be 50% or more in preschool children with chronic cough and that parental history of allergy and formula milk feeding may be associated with allergic sensitization.

Keyword

Cough; Preschool child; Asthma

MeSH Terms

Allergens
Alternaria
Animals
Asthma
Cats
Child
Child, Preschool*
Cockroaches
Cough*
Dander
Dermatitis, Atopic
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Dogs
Eosinophils
Epithelium
Humans
Hypersensitivity
Immunoglobulin E
Medical Records
Milk
Milk, Human
Parents
Respiratory Sounds
Respiratory Tract Infections
Rhinitis
Risk Factors*
Allergens
Immunoglobulin E

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