Cancer Res Treat.  2014 Apr;46(2):141-147.

Clinical Features and Treatment of Collecting Duct Carcinoma of the Kidney from the Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee

Affiliations
  • 1Division of Hematology-Oncology, Department of Internal Medicine, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea.
  • 2Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
  • 3Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. rha7655@yuhs.ac
  • 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 6Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 7Division of Hematology/Oncology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
  • 8Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
  • 9Division of Medical Oncology, Department of Internal Medicine, The Catholic University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
Collecting duct carcinoma (CDC) of the kidney is an aggressive disease with a poor prognosis, accountings for less than 1% of all renal cancers. To date, no standard therapy for CDC has been established. The aim of this study is an investigation of clinicopathologic findings of CDC and correlation of the disease status with a prognosis.
MATERIALS AND METHODS
From 1996 to 2009, 35 patients with CDC were treated at eight medical centers. The diagnosis of CDC was made based on nephrectomy in 27 cases and renal biopsy in eight cases.
RESULTS
Median PFS and OS for all patients were 5.8 months (95% CI 3.5 to 9.2) and 54.4 months (95% CI 0 to 109.2), respectively. The OS of patients with Stages I-III was 69.9 months (95% CI 54.0 to 85.8), while that of patients with Stage IV was 8.6 months (95% CI 0 to 23.3), which showed a statistically significant difference (p=0.01). In addition, among patients with Stage IV, the OS of patients who received a palliative treatment (immunotherapy, chemotherapy, or targeted therapy) was 18.4 months, which was higher than the OS of patients without treatment of 4.5 months.
CONCLUSION
CDC is a highly aggressive form of renal cell carcinoma. Despite most of the treatments, PFS and OS were short, however, there were some long-term survivors, therefore, conduct of additional research on the predictive markers of the several clinical, pathological differences and their treatments will be necessary.

Keyword

Renal cell carcinoma; Kidney; Treatment; Prognosis

MeSH Terms

Biopsy
Carcinoma, Renal Cell*
Centers for Disease Control and Prevention (U.S.)
Diagnosis
Drug Therapy
Gynecology*
Humans
Kidney
Kidney Neoplasms
Nephrectomy
Palliative Care
Prognosis
Survivors

Figure

  • Fig. 1 Summary of treatment results. MVAC, methotrexate, vinblastin, Adriamycin, and cisplatin; IFN, interferon; NED, no evidence of disease; 5-FU, 5-fluorouracil; IL-2, interleukin-2; GMAC, gemcitabine, methotrexate, Adriamycin, and cisplatin; GP, gemcitabine and cisplatin; GC, gemcitabine and carboplatin.

  • Fig. 2 Progression free survival (PFS) for all patients. CI, confidence interval.

  • Fig. 3 Overall survival (OS). (A) OS for all patients. (B) OS for patients with stage I-III (red) and IV (green). OS, overall survival; CI, confidence interval.


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