Allergy Asthma Immunol Res.  2016 Jan;8(1):41-48. 10.4168/aair.2016.8.1.41.

The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy

• Yu J
• Ahn K
• Shin YH
• Kim KW
• Suh DI
• Yu HS
• Kang MJ
• Lee KS
• Hong SA
• Choi KY
• Lee E
• Yang SI
• Seo JH
• Kim BJ
• Kim HB
• Lee SY
• Choi SJ
• Oh SY
• Kwon JY
• Lee KJ
• Park HJ
• Lee PR
• Won HS
• Hong SJ
• COCOA study group

• KMID: 2166648
• DOI: http://doi.org/10.4168/aair.2016.8.1.41

Abstract

PURPOSE
Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy.
METHODS
This study included 1,002 mother-neonate pairs from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). Prenatal environmental factors were collected using a questionnaire. The levels of CB IgE were measured by the ImmunoCAP system, and DNA was extracted from CB.
RESULTS
Exposure to home renovation during the prenatal period was associated with significantly higher levels of CB IgE only in neonates from atopic mothers, and the effect of renovation exposure on CB IgE levels persisted from 31 months before birth. Furthermore, prenatal exposure to home renovation increased the risk of CB IgE response interacting with polymorphisms of NRF2 and GSTP1 genes only in neonates from atopic mothers.
CONCLUSIONS
Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.

Keyword

Cord blood; gene-environment interaction; IgE; prenatal; reactive oxygen species; renovation; single nucleotide polymorphism

MeSH Terms

Asthma
Cohort Studies
DNA
Fetal Blood*
Gene-Environment Interaction
Humans
Hypersensitivity
Immunoglobulin E*
Infant, Newborn
Mothers
Oxidative Stress
Parturition
Polymorphism, Single Nucleotide
Reactive Oxygen Species*
Risk Factors
DNA
Immunoglobulin E
Reactive Oxygen Species

Figure

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  Figure Enrollment and outcomes.

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