Cancer Res Treat.  2003 Oct;35(5):373-382.

Combined Modality Therapy for Locally Advanced Non-Small Cell Lung Cancer

Affiliations
  • 1University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer, Department of Radiation Oncology, U.S.A. lcho@utsouthwestern.edu
  • 2University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer, Division of Thoracic Surgery, U.S.A.
  • 3University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer, Division of Hematology and Oncology, U.S.A.

Abstract

The majority of non-small cell lung cancer patients present with locally advanced disease that may not be resectable. A single modality treatment such as thoracic radiotherapy often results in an inferior outcome when compared to combined modality treatment. Various combinations of radiotherapy, chemotherapy, and surgery have been tested in patients with locally advanced non-small-celllung cancer with promising results. The favorable results of the combined modality treatment are accompanied by a corresponding increase in treatment related morbidity. In this article, the results of the application of combined modality treatments in the management of locally advanced non-small cell lung cancer are reviewed.

Keyword

Non-small cell lung cancer; Neoadjuvant chemotherapy; Radiotherapy

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Combined Modality Therapy*
Drug Therapy
Humans
Radiotherapy
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