Exp Neurobiol.  2016 Feb;25(1):24-32. 10.5607/en.2016.25.1.24.

Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling

Affiliations
  • 1Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea. jelee@yuhs.ac
  • 2BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
  • 3Department of Psychiatry, Yonsei University College of Medicine, Seoul 03722, Korea.
  • 4Department of Pharmacology, Yonsei University College of Medicine, Seoul 03722, Korea.
  • 5Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul 03722, Korea.

Abstract

Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and the alteration of cellular homeostasis. Agmatine, which is biosynthesized by arginine decarboxylation, has been reported in previous in vitro to exert a protective effect against various stresses. In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Moreover, the senescence associated-beta-galatosidase's activity in high glucose exposed neuronal cells was reduced by agmatine. Increased p21 and reduced p53 in high glucose conditioned cells were changed by agmatine. Ultimately, agmatine inhibits the neuronal cell senescence through the activation of p53 and the inhibition of p21. Here, we propose that agmatine may ameliorate neuronal cell senescence in hyperglycemia.

Keyword

Agmatine; High glucose; Hyperglycemia; Cell death; Senescence; Pro-inflammatory cytokines; p53; p21

MeSH Terms

Aging
Agmatine*
Arginine
Cell Aging*
Cell Death
Cytokines
Decarboxylation
Diabetes Mellitus
Diabetic Neuropathies
Glucose
Homeostasis
Hyperglycemia
Interleukin-6
Neurons*
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Agmatine
Arginine
Cytokines
Glucose
Interleukin-6
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
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