Clin Endosc.  2011 Sep;44(1):22-26.

Comparison of Midazolam Alone versus Midazolam Plus Propofol during Endoscopic Submucosal Dissection

• Cho YS
• Seo E
• Han JH
• Yoon SM
• Chae HB
• Park SM
• Youn SJ

Abstract

BACKGROUND/AIMS
For proper sedation during endoscopic submucosal dissection (ESD), propofol has been widely used. This study aimed to compare the levels of sedation and tolerance of patients treated with midazolam (M group) and a combination of midazolam and propofol (MP group) during ESD.
METHODS
A total of 44 consecutive patients undergoing ESD were randomly assigned to the two groups. In the M group, 2 mg of midazolam was given repeatedly to maintain after a loading dose of 5 mg. The MP group initially received 5 mg of midazolam and 20 mg of propofol. Then, we increased the dosage of propofol by 20 mg gradually.
RESULTS
The average amount of midazolam was 12 mg in the M group. In the M group, 10 patients were given propofol additionally, since they failed to achieve proper sedation. The average amount of propofol was 181 mg in the MP group. Procedure time, vital signs and rates of complications were not significantly different between two groups. Movement of patients and discomfort were lower in the MP group.
CONCLUSIONS
During ESD, treatment with propofol and a low dose of midazolam for sedation provides greater satisfaction for endoscopists compared to midazolam alone.

Keyword

Endoscopic submucosal dissection; Sedation; Midazolam; Propofol

MeSH Terms

Humans
Midazolam
Propofol
Vital Signs
Midazolam
Propofol

Figure

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  Fig. 1 Comparison of operator's satisfaction score between midazolam alone (M group) and a combination of midazolam and propofol (MP group).

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