Clin Endosc.  2014 Sep;47(5):432-439. 10.5946/ce.2014.47.5.432.

Endoscopic Ultrasound-Guided Treatment beyond Drainage: Hemostasis, Anastomosis, and Others

• Widmer JL
• Michel K

• KMID: 2165376
• DOI: http://doi.org/10.5946/ce.2014.47.5.432

Abstract

Since the introduction of endoscopic ultrasound (EUS) in the 1990s, it has evolved from a primarily diagnostic modality into an instrument that can be used in various therapeutic interventions. EUS-guided fine-needle injection was initially described for celiac plexus neurolysis. By using the fundamentals of this method, drainage techniques emerged for the biliary and pancreatic ducts, fluid collections, and abscesses. More recently, EUS has been used for ablative techniques and injection therapies for patients with for gastrointestinal malignancies. As the search for minimally invasive techniques continued, EUS-guided hemostasis methods have also been described. The technical advances in EUS-guided therapies may appear to be limitless; however, in many instances, these procedures have been described only in small case series. More data are required to determine the efficacy and safety of these techniques, and new accessories will be needed to facilitate their implementation into practice.

Keyword

Endosonography; Therapeutic endoscopy; Endoscopic ultrasound-guided drainage; Endoscopic ultrasound-guided intervention

MeSH Terms

Abscess
Celiac Plexus
Drainage*
Endosonography
Hemostasis*
Humans
Pancreatic Ducts
Ultrasonography

Reference

1. Erickson RA. EUS-guided FNA. Gastrointest Endosc. 2004; 60:267–279. PMID: 15278063.

2. Chen VK, Eloubeidi MA. Endoscopic ultrasound-guided fine needle aspiration is superior to lymph node echofeatures: a prospective evaluation of mediastinal and peri-intestinal lymphadenopathy. Am J Gastroenterol. 2004; 99:628–633. PMID: 15089893.

3. Harewood GC, Wiersema MJ. Endosonography-guided fine needle aspiration biopsy in the evaluation of pancreatic masses. Am J Gastroenterol. 2002; 97:1386–1391. PMID: 12094855.

4. Moparty B, Logroño R, Nealon WH, et al. The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions. Diagn Cytopathol. 2007; 35:18–25. PMID: 17173300.

5. Al-Haddad M, Raimondo M, Woodward T, et al. Safety and efficacy of cytology brushings versus standard FNA in evaluating cystic lesions of the pancreas: a pilot study. Gastrointest Endosc. 2007; 65:894–898. PMID: 17210151.

6. Gress F, Gottlieb K, Sherman S, Lehman G. Endoscopic ultrasonography-guided fine-needle aspiration biopsy of suspected pancreatic cancer. Ann Intern Med. 2001; 134:459–464. PMID: 11255521.

7. Fritscher-Ravens A, Soehendra N, Schirrow L, et al. Role of transesophageal endosonography-guided fine-needle aspiration in the diagnosis of lung cancer. Chest. 2000; 117:339–345. PMID: 10669672.

8. Vazquez-Sequeiros E, Olcina JR. Endoscopic ultrasound guided vascular access and therapy: a promising indication. World J Gastrointest Endosc. 2010; 2:198–202. PMID: 21160933.

9. Seicean A. Celiac plexus neurolysis in pancreatic cancer: the endoscopic ultrasound approach. World J Gastroenterol. 2014; 20:110–117. PMID: 24415863.

10. Puli SR, Reddy JB, Bechtold ML, Antillon MR, Brugge WR. EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review. Dig Dis Sci. 2009; 54:2330–2337. PMID: 19137428.

11. Gress F, Schmitt C, Sherman S, Ikenberry S, Lehman G. A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain. Am J Gastroenterol. 1999; 94:900–905. PMID: 10201454.

12. Levy MJ, Chari ST, Wiersema MJ. Endoscopic ultrasound-guided celiac neurolysis. Gastrointest Endosc Clin N Am. 2012; 22:231–247. PMID: 22632946.

13. Tarantino I, Barresi L. Interventional endoscopic ultrasound: therapeutic capability and potential. World J Gastrointest Endosc. 2009; 1:39–44. PMID: 21160649.

14. Lee KH, Lee JK. Interventional endoscopic ultrasonography: present and future. Clin Endosc. 2011; 44:6–12. PMID: 22741106.

15. Gress F. Endoscopic ultrasound-guided celiac plexus neurolysis. Gastroenterol Hepatol (N Y). 2007; 3:279–281. PMID: 21960841.

16. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62:102–111. PMID: 23100216.

17. Baron TH, Harewood GC, Morgan DE, Yates MR. Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc. 2002; 56:7–17. PMID: 12085029.

18. Baron TH, Morgan DE. The diagnosis and management of fluid collections associated with pancreatitis. Am J Med. 1997; 102:555–563. PMID: 9217671.

19. Yeo CJ, Bastidas JA, Lynch-Nyhan A, Fishman EK, Zinner MJ, Cameron JL. The natural history of pancreatic pseudocysts documented by computed tomography. Surg Gynecol Obstet. 1990; 170:411–417. PMID: 2326721.

20. Bradley EL, Clements JL Jr, Gonzalez AC. The natural history of pancreatic pseudocysts: a unified concept of management. Am J Surg. 1979; 137:135–141. PMID: 758840.

21. Gouyon B, Lévy P, Ruszniewski P, et al. Predictive factors in the outcome of pseudocysts complicating alcoholic chronic pancreatitis. Gut. 1997; 41:821–825. PMID: 9462217.

22. Topazian M. Endoscopic ultrasound-guided drainage of pancreatic fluid collections (with video). Clin Endosc. 2012; 45:337–340. PMID: 22977831.

23. Varadarajulu S, Wilcox CM, Tamhane A, Eloubeidi MA, Blakely J, Canon CL. Role of EUS in drainage of peripancreatic fluid collections not amenable for endoscopic transmural drainage. Gastrointest Endosc. 2007; 66:1107–1119. PMID: 17892874.

24. Kruger M, Schneider AS, Manns MP, Meier PN. Endoscopic management of pancreatic pseudocysts or abscesses after an EUS-guided 1-step procedure for initial access. Gastrointest Endosc. 2006; 63:409–416. PMID: 16500388.

25. Lopes CV, Pesenti C, Bories E, Caillol F, Giovannini M. Endoscopic-ultrasound-guided endoscopic transmural drainage of pancreatic pseudocysts and abscesses. Scand J Gastroenterol. 2007; 42:524–529. PMID: 17454865.

26. Antillon MR, Shah RJ, Stiegmann G, Chen YK. Single-step EUS-guided transmural drainage of simple and complicated pancreatic pseudocysts. Gastrointest Endosc. 2006; 63:797–803. PMID: 16650541.

27. Varadarajulu S. EUS followed by endoscopic pancreatic pseudocyst drainage or all-in-one procedure: a review of basic techniques (with video). Gastrointest Endosc. 2009; 69(2 Suppl):S176–S181. PMID: 19179152.

28. Puri R, Mishra SR, Thandassery RB, Sud R, Eloubeidi MA. Outcome and complications of endoscopic ultrasound guided pancreatic pseudocyst drainage using combined endoprosthesis and naso-cystic drain. J Gastroenterol Hepatol. 2012; 27:722–727. PMID: 22313377.

29. Talreja JP, Shami VM, Ku J, Morris TD, Ellen K, Kahaleh M. Transenteric drainage of pancreatic-fluid collections with fully covered self-expanding metallic stents (with video). Gastrointest Endosc. 2008; 68:1199–1203. PMID: 19028232.

30. Fabbri C, Luigiano C, Cennamo V, et al. Endoscopic ultrasound-guided transmural drainage of infected pancreatic fluid collections with placement of covered self-expanding metal stents: a case series. Endoscopy. 2012; 44:429–433. PMID: 22382852.

31. Penn DE, Draganov PV, Wagh MS, Forsmark CE, Gupte AR, Chauhan SS. Prospective evaluation of the use of fully covered self-expanding metal stents for EUS-guided transmural drainage of pancreatic pseudocysts. Gastrointest Endosc. 2012; 76:679–684. PMID: 22732874.

32. Itoi T, Binmoeller KF, Shah J, et al. Clinical evaluation of a novel lumen-apposing metal stent for endosonography-guided pancreatic pseudocyst and gallbladder drainage (with videos). Gastrointest Endosc. 2012; 75:870–876. PMID: 22301347.

33. Banks PA, Freeman ML. Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006; 101:2379–2400. PMID: 17032204.

34. Sarkaria S, Sethi A, Rondon C, et al. Pancreatic necrosectomy using covered esophageal stents: a novel approach. J Clin Gastroenterol. 2014; 48:145–152. PMID: 23751853.

35. Bakker OJ, van Santvoort HC, van Brunschot S, et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA. 2012; 307:1053–1061. PMID: 22416101.

36. Sadik R, Kalaitzakis E, Thune A, Hansen J, Jonson C. EUS-guided drainage is more successful in pancreatic pseudocysts compared with abscesses. World J Gastroenterol. 2011; 17:499–505. PMID: 21274380.

37. Varadarajulu S, Phadnis MA, Christein JD, Wilcox CM. Multiple transluminal gateway technique for EUS-guided drainage of symptomatic walled-off pancreatic necrosis. Gastrointest Endosc. 2011; 74:74–80. PMID: 21612778.

38. Kuligowska E, Keller E, Ferrucci JT. Treatment of pelvic abscesses: value of one-step sonographically guided transrectal needle aspiration and lavage. AJR Am J Roentgenol. 1995; 164:201–206. PMID: 7998540.

39. Noh SH, Park do H, Kim YR, et al. EUS-guided drainage of hepatic abscesses not accessible to percutaneous drainage (with videos). Gastrointest Endosc. 2010; 71:1314–1319. PMID: 20400078.

40. Kahaleh M, Wang P, Shami VM, Tokar J, Yeaton P. Drainage of gallbladder fossa fluid collections with endoprosthesis placement under endoscopic ultrasound guidance: a preliminary report of two cases. Endoscopy. 2005; 37:393–396. PMID: 15824954.

41. Shami VM, Talreja JP, Mahajan A, Phillips MS, Yeaton P, Kahaleh M. EUS-guided drainage of bilomas: a new alternative? Gastrointest Endosc. 2008; 67:136–140. PMID: 18155436.

42. Giovannini M, Bories E, Moutardier V, et al. Drainage of deep pelvic abscesses using therapeutic echo endoscopy. Endoscopy. 2003; 35:511–514. PMID: 12783350.

43. Ulla-Rocha JL, Vilar-Cao Z, Sardina-Ferreiro R. EUS-guided drainage and stent placement for postoperative intra-abdominal and pelvic fluid collections in oncological surgery. Therap Adv Gastroenterol. 2012; 5:95–102.

44. Lee DH, Cash BD, Womeldorph CM, Horwhat JD. Endoscopic therapy of a splenic abscess: definitive treatment via EUS-guided transgastric drainage. Gastrointest Endosc. 2006; 64:631–634. PMID: 16996360.

45. Singhal S, Changela K, Lane D, Anand S, Duddempudi S. Endoscopic ultrasound-guided hepatic and perihepatic abscess drainage: an evolving technique. Therap Adv Gastroenterol. 2014; 7:93–98.

46. Fernandez-Urien I, Vila JJ, Jimenez FJ. Endoscopic ultrasound-guided drainage of pelvic collections and abscesses. World J Gastrointest Endosc. 2010; 2:223–227. PMID: 21160937.

47. Varadarajulu S, Drelichman ER. EUS-guided drainage of pelvic abscess (with video). Gastrointest Endosc. 2007; 66:372–376. PMID: 17643716.

48. Trevino JM, Drelichman ER, Varadarajulu S. Modified technique for EUS-guided drainage of pelvic abscess (with video). Gastrointest Endosc. 2008; 68:1215–1219. PMID: 19028235.

49. Varadarajulu S, Drelichman ER. Effectiveness of EUS in drainage of pelvic abscesses in 25 consecutive patients (with video). Gastrointest Endosc. 2009; 70:1121–1127. PMID: 19962502.

50. Seewald S, Ang TL, Teng KY, et al. Endoscopic ultrasound-guided drainage of abdominal abscesses and infected necrosis. Endoscopy. 2009; 41:166–174. PMID: 19214899.

51. Baron TH, Petersen BT, Mergener K, et al. Quality indicators for endoscopic retrograde cholangiopancreatography. Am J Gastroenterol. 2006; 101:892–897. PMID: 16635233.

52. Wiersema MJ, Sandusky D, Carr R, Wiersema LM, Erdel WC, Frederick PK. Endosonography-guided cholangiopancreatography. Gastrointest Endosc. 1996; 43(2 Pt 1):102–106. PMID: 8635700.

53. Iqbal S, Friedel DM, Grendell JH, Stavropoulos SN. Outcomes of endoscopic-ultrasound-guided cholangiopancreatography: a literature review. Gastroenterol Res Pract. 2013; 2013:869214. PMID: 23573080.

54. Kedia P, Gaidhane M, Kahaleh M. Endoscopic guided biliary drainage: how can we achieve efficient biliary drainage? Clin Endosc. 2013; 46:543–551. PMID: 24143319.

55. Yamao K, Hara K, Mizuno N, et al. EUS-guided biliary drainage. Gut Liver. 2010; 4(Suppl 1):S67–S75. PMID: 21103298.

56. Yamao K, Sawaki A, Takahashi K, Imaoka H, Ashida R, Mizuno N. EUS-guided choledochoduodenostomy for palliative biliary drainage in case of papillary obstruction: report of 2 cases. Gastrointest Endosc. 2006; 64:663–667. PMID: 16996372.

57. Kahaleh M, Artifon EL, Perez-Miranda M, et al. Endoscopic ultrasonography guided biliary drainage: summary of consortium meeting, May 7th, 2011, Chicago. World J Gastroenterol. 2013; 19:1372–1379. PMID: 23538784.

58. Widmer J, Sharaiha RZ, Kahaleh M. Endoscopic ultrasonography-guided drainage of the pancreatic duct. Gastrointest Endosc Clin N Am. 2013; 23:847–861. PMID: 24079794.

59. Tessier G, Bories E, Arvanitakis M, et al. EUS-guided pancreatogastrostomy and pancreatobulbostomy for the treatment of pain in patients with pancreatic ductal dilatation inaccessible for transpapillary endoscopic therapy. Gastrointest Endosc. 2007; 65:233–241. PMID: 17258981.

60. Barkay O, Sherman S, McHenry L, et al. Therapeutic EUS-assisted endoscopic retrograde pancreatography after failed pancreatic duct cannulation at ERCP. Gastrointest Endosc. 2010; 71:1166–1173. PMID: 20303489.

61. Widmer J, Singhal S, Gaidhane M, Kahaleh M. Endoscopic ultrasound-guided endoluminal drainage of the gallbladder. Dig Endosc. 2014; 26:525–531. PMID: 24422762.

62. Perez-Miranda M, De la Serna-Higuera C. EUS access to the biliary tree. Curr Gastroenterol Rep. 2013; 15:349. PMID: 24014119.

63. Widmer J, Alvarez P, Gaidhane M, et al. Endoscopic ultrasonography-guided cholecystogastrostomy in patients with unresectable pancreatic cancer using anti-migratory metal stents: a new approach. Dig Endosc. 2014; 26:599–602. PMID: 24102709.

64. Jang JW, Lee SS, Park do H, Seo DW, Lee SK, Kim MH. Feasibility and safety of EUS-guided transgastric/transduodenal gallbladder drainage with single-step placement of a modified covered self-expandable metal stent in patients unsuitable for cholecystectomy. Gastrointest Endosc. 2011; 74:176–181. PMID: 21704816.

65. Adsay NV, Bagci P, Tajiri T, et al. Pathologic staging of pancreatic, ampullary, biliary, and gallbladder cancers: pitfalls and practical limitations of the current AJCC/UICC TNM staging system and opportunities for improvement. Semin Diagn Pathol. 2012; 29:127–141. PMID: 23062420.

66. de la Serna-Higuera C, Pérez-Miranda M, Gil-Simón P, et al. EUS-guided transenteric gallbladder drainage with a new fistula-forming, lumen-apposing metal stent. Gastrointest Endosc. 2013; 77:303–308. PMID: 23206813.

67. Gan SI, Thompson CC, Lauwers GY, Bounds BC, Brugge WR. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc. 2005; 61:746–752. PMID: 15855986.

68. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study. Gastrointest Endosc. 2009; 70:710–723. PMID: 19577745.

69. DiMaio CJ, DeWitt JM, Brugge WR. Ablation of pancreatic cystic lesions: the use of multiple endoscopic ultrasound-guided ethanol lavage sessions. Pancreas. 2011; 40:664–668. PMID: 21562447.

70. Oh HC, Seo DW, Song TJ, et al. Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology. 2011; 140:172–179. PMID: 20950614.

71. Oh HC, Seo DW, Lee TY, et al. New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection. Gastrointest Endosc. 2008; 67:636–642. PMID: 18262182.

72. Gunter E, Lingenfelser T, Eitelbach F, Müller H, Ell C. EUS-guided ethanol injection for treatment of a GI stromal tumor. Gastrointest Endosc. 2003; 57:113–115. PMID: 12518147.

73. Jurgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stölzel U. EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc. 2006; 63:1059–1062. PMID: 16733126.

74. Artifon EL, Lucon AM, Sakai P, et al. EUS-guided alcohol ablation of left adrenal metastasis from non-small-cell lung carcinoma. Gastrointest Endosc. 2007; 66:1201–1205. PMID: 18061721.

75. Barclay RL, Perez-Miranda M, Giovannini M. EUS-guided treatment of a solid hepatic metastasis. Gastrointest Endosc. 2002; 55:266–270. PMID: 11818938.

76. Carrara S, Arcidiacono PG, Albarello L, et al. Endoscopic ultrasound-guided application of a new internally gas-cooled radiofrequency ablation probe in the liver and spleen of an animal model: a preliminary study. Endoscopy. 2008; 40:759–763. PMID: 18702032.

77. Brugge WR. EUS-guided tumor ablation with heat, cold, microwave, or radiofrequency: will there be a winner? Gastrointest Endosc. 2009; 69(2 Suppl):S212–S216. PMID: 19179160.

78. Goldberg SN, Mallery S, Gazelle GS, Brugge WR. EUS-guided radiofrequency ablation in the pancreas: results in a porcine model. Gastrointest Endosc. 1999; 50:392–401. PMID: 10462663.

79. Gaidhane M, Smith I, Ellen K, et al. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) of the pancreas in a porcine model. Gastroenterol Res Pract. 2012; 2012:431451. PMID: 23049547.

80. Carrara S, Arcidiacono PG, Albarello L, et al. Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study. Endoscopy. 2008; 40:321–326. PMID: 18389449.

81. Regula J, MacRobert AJ, Gorchein A, et al. Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX: a pilot study. Gut. 1995; 36:67–75. PMID: 7890239.

82. Overholt B, Panjehpour M, Tefftellar E, Rose M. Photodynamic therapy for treatment of early adenocarcinoma in Barrett's esophagus. Gastrointest Endosc. 1993; 39:73–76. PMID: 8454152.

83. Bown SG, Rogowska AZ, Whitelaw DE, et al. Photodynamic therapy for cancer of the pancreas. Gut. 2002; 50:549–557. PMID: 11889078.

84. Chan HH, Nishioka NS, Mino M, et al. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc. 2004; 59:95–99. PMID: 14722560.

85. Yusuf TE, Matthes K, Brugge WR. EUS-guided photodynamic therapy with verteporfin for ablation of normal pancreatic tissue: a pilot study in a porcine model (with video). Gastrointest Endosc. 2008; 67:957–961. PMID: 18178203.

86. Hecht JR, Bedford R, Abbruzzese JL, et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res. 2003; 9:555–561. PMID: 12576418.

87. Chang KY, Lee YD. Ring-opening polymerization of epsilon-caprolactone initiated by the antitumor agent doxifluridine. Acta Biomater. 2009; 5:1075–1081. PMID: 19101214.

88. Chang KJ, Lee JG, Holcombe RF, Kuo J, Muthusamy R, Wu ML. Endoscopic ultrasound delivery of an antitumor agent to treat a case of pancreatic cancer. Nat Clin Pract Gastroenterol Hepatol. 2008; 5:107–111. PMID: 18253139.

89. Chang KJ, Nguyen PT, Thompson JA, et al. Phase I clinical trial of allogeneic mixed lymphocyte culture (cytoimplant) delivered by endoscopic ultrasound-guided fine-needle injection in patients with advanced pancreatic carcinoma. Cancer. 2000; 88:1325–1335. PMID: 10717613.

90. Pishvaian AC, Collins B, Gagnon G, Ahlawat S, Haddad NG. EUS-guided fiducial placement for CyberKnife radiotherapy of mediastinal and abdominal malignancies. Gastrointest Endosc. 2006; 64:412–417. PMID: 16923491.

91. Savides TJ. EUS-guided fine-needle insertion of radiopaque fiducials: X marks the spot. Gastrointest Endosc. 2006; 64:418–419. PMID: 16923492.

92. Sanders MK, Moser AJ, Khalid A, et al. EUS-guided fiducial placement for stereotactic body radiotherapy in locally advanced and recurrent pancreatic cancer. Gastrointest Endosc. 2010; 71:1178–1184. PMID: 20362284.

93. Park WG, Yan BM, Schellenberg D, et al. EUS-guided gold fiducial insertion for image-guided radiation therapy of pancreatic cancer: 50 successful cases without fluoroscopy. Gastrointest Endosc. 2010; 71:513–518. PMID: 20189509.

94. Sun S, Xu H, Xin J, Liu J, Guo Q, Li S. Endoscopic ultrasound-guided interstitial brachytherapy of unresectable pancreatic cancer: results of a pilot trial. Endoscopy. 2006; 38:399–403. PMID: 16680642.

95. Jin Z, Du Y, Li Z, Jiang Y, Chen J, Liu Y. Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study. Endoscopy. 2008; 40:314–320. PMID: 18283622.

96. Order SE, Siegel JA, Principato R, et al. Selective tumor irradiation by infusional brachytherapy in nonresectable pancreatic cancer: a phase I study. Int J Radiat Oncol Biol Phys. 1996; 36:1117–1126. PMID: 8985034.

97. Maier W, Henne K, Krebs A, Schipper J. Endoscopic ultrasound-guided brachytherapy of head and neck tumours. A new procedure for controlled application. J Laryngol Otol. 1999; 113:41–48. PMID: 10341918.

98. Lah JJ, Kuo JV, Chang KJ, Nguyen PT. EUS-guided brachytherapy. Gastrointest Endosc. 2005; 62:805–808. PMID: 16246706.

99. Levy MJ, Chak A. EUS 2008 Working Group document: evaluation of EUS-guided vascular therapy. Gastrointest Endosc. 2009; 69(2 Suppl):S37–S42. PMID: 19179168.

100. Wong RC, Farooq FT, Chak A. Endoscopic Doppler US probe for the diagnosis of gastric varices (with videos). Gastrointest Endosc. 2007; 65:491–496. PMID: 17321253.

101. Wong RC. Endoscopic Doppler US probe for acute peptic ulcer hemorrhage. Gastrointest Endosc. 2004; 60:804–812. PMID: 15557966.

102. Kuramochi A, Imazu H, Kakutani H, Uchiyama Y, Hino S, Urashima M. Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatment. J Gastroenterol. 2007; 42:219–224. PMID: 17380280.

103. van Leerdam ME, Rauws EA, Geraedts AA, Tijssen JG, Tytgat GN. The role of endoscopic Doppler US in patients with peptic ulcer bleeding. Gastrointest Endosc. 2003; 58:677–684. PMID: 14595300.

104. Ribeiro A, Vazquez-Sequeiros E, Wiersema MJ. Doppler EUS-guided treatment of gastric Dieulafoy's lesion. Gastrointest Endosc. 2001; 53:807–809. PMID: 11375598.

105. Kohler B, Riemann JF. Endoscopic injection therapy of Forrest II and III gastroduodenal ulcers guided by endoscopic Doppler ultrasound. Endoscopy. 1993; 25:219–223. PMID: 8519240.

106. Lee YT, Chan FK, Ng EK, et al. EUS-guided injection of cyanoacrylate for bleeding gastric varices. Gastrointest Endosc. 2000; 52:168–174. PMID: 10922086.

107. de Paulo GA, Ardengh JC, Nakao FS, Ferrari AP. Treatment of esophageal varices: a randomized controlled trial comparing endoscopic sclerotherapy and EUS-guided sclerotherapy of esophageal collateral veins. Gastrointest Endosc. 2006; 63:396–402. PMID: 16500386.

108. Levy MJ, Wong Kee, Farnell MB, Misra S, Sarr MG, Gostout CJ. Endoscopic ultrasound (EUS)-guided angiotherapy of refractory gastrointestinal bleeding. Am J Gastroenterol. 2008; 103:352–359. PMID: 17986314.

109. Gonzalez JM, Ezzedine S, Vitton V, Grimaud JC, Barthet M. Endoscopic ultrasound treatment of vascular complications in acute pancreatitis. Endoscopy. 2009; 41:721–724. PMID: 19670142.

110. Roberts KJ, Jones RG, Forde C, Marudanayagam R. Endoscopic ultrasound-guided treatment of visceral artery pseudoaneurysm. HPB (Oxford). 2012; 14:489–490. PMID: 22672553.

111. Romero-Castro R, Pellicer-Bautista FJ, Jimenez-Saenz M, et al. EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices: results in 5 cases. Gastrointest Endosc. 2007; 66:402–407. PMID: 17643723.

112. Giday SA, Clarke JO, Buscaglia JM, et al. EUS-guided portal vein catheterization: a promising novel approach for portal angiography and portal vein pressure measurements. Gastrointest Endosc. 2008; 67:338–342. PMID: 18226699.

113. Giday SA, Ko CW, Clarke JO, et al. EUS-guided portal vein carbon dioxide angiography: a pilot study in a porcine model. Gastrointest Endosc. 2007; 66:814–819. PMID: 17905028.

114. Brugge WR. EUS is an important new tool for accessing the portal vein. Gastrointest Endosc. 2008; 67:343–344. PMID: 18226700.

115. Lai L, Poneros J, Santilli J, Brugge W. EUS-guided portal vein catheterization and pressure measurement in an animal model: a pilot study of feasibility. Gastrointest Endosc. 2004; 59:280–283. PMID: 14745408.

116. Buscaglia JM, Dray X, Shin EJ, et al. A new alternative for a transjugular intrahepatic portosystemic shunt: EUS-guided creation of an intrahepatic portosystemic shunt (with video). Gastrointest Endosc. 2009; 69:941–947. PMID: 19327481.

117. Kedia P, Kumta NA, Sharaiha R, Kahaleh M. Bypassing the bypass: EUS-directed transgastric ERCP for Roux-en-Y anatomy. Gastrointest Endosc. 2014; 5. 15. Epub. DOI: http://dx.doi.org/10.1016/j.gie.2014.04.007.