Exp Neurobiol.  2008 Dec;17(2):63-69. 10.5607/en.2008.17.2.63.

Protective Effect of Orally Administrated Dandelion Against Carrageenan-induced Ankle Arthritis in Rats

Affiliations
  • 1Acupuncture & Meridian Science Research Center, Kyunghee University, Seoul 130-701, Korea. dhhahm@khu.ac.kr
  • 2Korea Food Research Institute, Seongnam 463-746, Korea
  • 3Department of Integrative Medicine, The Catholic University of KoreaCollege of Medicine, Seoul 137-701, Korea.

Abstract

Dandelion (DA) possesses the therapeutic ability to eliminate heat and alleviating swelling, choleresis, dieresis, and inflammation. In order to investigate the anti-arthritic effect of DA, several behavioral parameters such as paw volume, squeaking score, and weight distribution ratio were investigated in a carrageenan-induced arthritis rat model. At the maximum severity of arthritis, the daily administration of DA was initiated and lasted for 9 days. The therapeutic effects of DA were observed on 9th day after the arthritis induction, as compared to saline-treated control group. Oral administration of DA significantly alleviated apparent symptoms of paw volume, squeaking score, and weight distribution ratio in rats. In conclusion, DA was found to be effective in alleviating the inflammatory response and thus arthritic symptoms in carrageenan-induced arthritic rats.

Keyword

dandelion; arthritis; carrageenan; paw volume; squeaking score; weight distribution ratio
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