J Korean Med Sci.  2015 Aug;30(8):1136-1142. 10.3346/jkms.2015.30.8.1136.

Establishment of Reference Ranges for Prostate Volume and Annual Prostate Volume Change Rate in Korean Adult Men: Analyses of a Nationwide Screening Population

Affiliations
  • 1Department of Urology, Eulji University Hospital, Daejeon, Korea.
  • 2Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea. hllee61@hanmail.net
  • 3Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
  • 4Department of Urology, Boramae Medical Center, Seoul, Korea.
  • 5Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea.
  • 6Department of Urology, Konkuk University Hospital, Seoul, Korea.

Abstract

We aimed to determine normal reference ranges for prostate volume (PV) and annual PV change rate in a Korean nationwide screening population. Data from men who underwent a routine health check-up were collected from 13 university hospitals. The cohort comprised men aged > or =40 yr who had undergone 2 or more serial transrectal ultrasonographies. Men with initial PV>100 mL; serum PSA level>10 ng/mL; PV reduction>20% compared with initial PV, or who had history of prostate cancer or prostate surgery, were excluded. Linear regression and mixed effects regression analyses were used to predict mean PV and longitudinal change in PV over time. A total of 2,967 men formed the study cohort. Age, body mass index (BMI), and serum prostate-specific antigen (PSA) level were found to be significant predictors of PV. A predicted PV table, with a 95% confidence interval (CIs), was developed after adjusting for these 3 variables. Annual PV change rate was 0.51 mL/year (95% CI, 0.47-0.55). Annual PV change rate according to age was 0.68 mL/year, 0.84 mL/year, 1.09 mL/year, and 0.50 mL/year for subjects in their 40s, 50s, 60s, and > or =70 yr, respectively. Predicted annual PV change rate differed depending on age, BMI, serum PSA level and baseline PV. From a nationwide screening database, we established age-, PSA-, and BMI-specific reference ranges for PV and annual PV change rate in Korean men. Our newly established reference ranges for PV and annual PV change rate will be valuable in interpreting PV data in Korean men.

Keyword

Prostate; Benign Prostatic Hyperplasia; Growth; Korea

MeSH Terms

Adult
Aged
Aged, 80 and over
Aging/*pathology
Humans
Male
Mass Screening/*standards
Middle Aged
Organ Size
Prostate/*anatomy & histology/ultrasonography
Reference Values
Reproducibility of Results
Republic of Korea
Sensitivity and Specificity
Ultrasonography/*standards
Urology/*standards

Figure

  • Fig. 1 Predicted mean prostate volume (PV) and 95% confidence intervals (CI) according to age and predicted mean PV, further stratified by body mass index (BMI) and serum prostate specific antigen (PSA) level (upper column). Predicted mean transitional zone volume (TZV) and 95% CIs according to age and predicted mean TZV, further stratified by BMI and serum PSA level (lower column).


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