Korean J Perinatol.  2015 Dec;26(4):365-368. 10.14734/kjp.2015.26.4.365.

Prenatal Diagnosis of Fetal Goiter in a Euthyroid Mother

Affiliations
  • 1Department of Obstetrics and Gynecology, School of Medicine, Catholic University of Daegu, Korea. magu815@cu.ac.kr
  • 2Department of Pediatrics, School of Medicine, Catholic University of Daegu, Korea.

Abstract

Congenital fetal goiter is a very rare pathology, is sometimes difficult to diagnose when there is no maternal history or the goiter size is moderate. We report a case of prenatally diagnosed fetal goiter in a euthyroid mother. A 28-year-old woman was referred to our clinic at 38(+2) weeks of gestation. Ultrasonographic examination revealed a fetal goiter. The maternal history and thyroid function tests, including antithyroid autoantibody tests, were unremarkable. Cesarean section was performed, and the thyroid profile of the neonate was consistent with congenital hypothyroidism. Thyroxine therapy was immediately started. Fetal thyroid function must be determined when a goiter is detected. Cordocentesis is a more reliable but riskier diagnostic tool than amniocentesis. Intra-amniotic injection of thyroxine is relatively safe and an easier management option for fetal hypothyroidism. To develop more noninvasive and safe methods for therapeutic efficacy monitoring, a large-scale study is necessary.

Keyword

Congenital hypothyroidism; Goiter; Prenatal diagnosis

MeSH Terms

Adult
Amniocentesis
Cesarean Section
Congenital Hypothyroidism
Cordocentesis
Female
Goiter*
Humans
Hypothyroidism
Infant, Newborn
Mothers*
Pathology
Pregnancy
Prenatal Diagnosis*
Thyroid Function Tests
Thyroid Gland
Thyroxine
Thyroxine
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