Korean J Med Mycol.  2016 Mar;21(1):14-19. 10.17966/KJMM.2016.21.1.14.

A Case of Rhino-Orbital-Cerebral Mucormycosis Successfully Treated by Surgical Treatment and Posaconazole

• Seo Y
• Park J
• Jang T

• KMID: 2164136
• DOI: http://doi.org/10.17966/KJMM.2016.21.1.14

Abstract

Mucormycosis is a highly aggressive and fatal fungal infection. Due to its rapid progression, combination of early wide surgical debridement with administration of antifungal agent is extremely crucial. European Society for Clinical Microbiology and Infectious Diseases, and European Confedration of Medical Mycology recommended amphotericin B as the first-line of treatment and posaconazole as the salvage agent for mucormycosis. We report a case of rhino-orbital-cerebral mucormycosis successfully treated by changing antifungal agent from the first-line amphotericin B to the salvage agent posaconazole. A 57-years-old female with uncontrolled type 2 diabetes mellitus was presented with foot abscess and rhino-orbital-cerebral mucormycosis. The infection was intractable despite orbital orbital exenteration with surgical debridement and 2 months of antibiotics treatment including amphotericin B. Changing amphotericin B to posaconazole resulted in clinical improvement within the first week. Conclusively the newly administered antifungal agent, posaconazole is expected to be an effective salvage treatment option for mucormycosis after failure of initial treatment of amphotericin B with surgical management.

Keyword

Mucormycosis; Posaconazole; Salvage treatment; Surgical treatment

MeSH Terms

Abscess
Amphotericin B
Anti-Bacterial Agents
Communicable Diseases
Debridement
Diabetes Mellitus, Type 2
Female
Foot
Humans
Mucormycosis*
Mycology
Orbit
Amphotericin B
Anti-Bacterial Agents