Korean J Med.  2016 May;90(5):460-463. 10.3904/kjm.2016.90.5.460.

Myelodysplastic Syndrome (RAEB-II) Development 2 Months after Chemotherapy for a Primary Non-seminomatous Mediastinal Germ Cell Tumor

Affiliations
  • 1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. chulwon1.jung@samsung.com

Abstract

Here, we report on a 20-year-old patient with a primary nonseminomatous mediastinal germ cell tumor (MGCT) who developed myelodysplastic syndrome (MDS) 2 months following chemotherapy with cisplatin, etoposide, ifosfamide, and paclitaxel. Bone marrow examinations revealed that the MDS was a refractory anemia with excess type II blasts and complex chromosomal abnormalities. With the onset of MDS occurring rapidly following chemotherapy, it is unlikely to have been caused by the therapy. We discuss the association between primary nonseminomatous MGCTs and hematological malignancies, including the possibility of a common clonal origin.

Keyword

Mediastinal germ cell tumor; Myelodysplastic syndromes; Therapy-Related

MeSH Terms

Anemia, Refractory
Bone Marrow Examination
Chromosome Aberrations
Cisplatin
Drug Therapy*
Etoposide
Germ Cells*
Hematologic Neoplasms
Humans
Ifosfamide
Myelodysplastic Syndromes*
Neoplasms, Germ Cell and Embryonal*
Paclitaxel
Young Adult
Cisplatin
Etoposide
Ifosfamide
Paclitaxel
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