Korean J Pediatr.  2016 Apr;59(4):202-204. 10.3345/kjp.2016.59.4.202.

Deficiency of antidiuretic hormone: a rare cause of massive polyuria after kidney transplantation

• Jang KM
• Sohn YS
• Hwang YJ
• Choi BS
• Cho MH

• KMID: 2163114
• DOI: http://doi.org/10.3345/kjp.2016.59.4.202

Abstract

A 15-year-old boy, who was diagnosed with Alport syndrome and end-stage renal disease, received a renal transplant from a living-related donor. On postoperative day 1, his daily urine output was 10,000 mL despite normal graft function. His laboratory findings including urine, serum osmolality, and antidiuretic hormone levels showed signs similar to central diabetes insipidus, so he was administered desmopressin acetate nasal spray. After administering the desmopressin, urine specific gravity and osmolality increased abruptly, and daily urine output declined to the normal range. The desmopressin acetate was tapered gradually and discontinued 3 months later. Graft function was good, and urine output was maintained within the normal range without desmopressin 20 months after the transplantation. We present a case of a massive polyuria due to transient deficiency of antidiuretic hormone with the necessity of desmopressin therapy immediately after kidney transplantation in a pediatric patient.

Keyword

Polyuria; Antidiuretic hormone; Kidney transplantation

MeSH Terms

Adolescent
Deamino Arginine Vasopressin
Diabetes Insipidus, Neurogenic
Humans
Kidney Failure, Chronic
Kidney Transplantation*
Kidney*
Male
Nephritis, Hereditary
Osmolar Concentration
Polyuria*
Reference Values
Specific Gravity
Tissue Donors
Transplants
Deamino Arginine Vasopressin