Korean J Otorhinolaryngol-Head Neck Surg.  2016 Apr;59(4):304-308. 10.3342/kjorl-hns.2016.59.4.304.

Two Cases of Immunoglobulin G4-Related Sclerosing Disease Mimicking Nasopharyngeal Carcinoma

  • 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Korea. jyb20000@hanyang.ac.kr


Immunoglobulin G4 (IgG4)-related sclerosing disease is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasma cell. This disease can occur in the salivary, lacrimal and pituitary gland in the head and neck region. The involvement of IgG4-related sclerosing disease at nasopharynx is extremely rare, so it is hard to make an accurate diagnosis. Recently, we have experienced two cases of IgG4-related sclerosing disease arising from the nasopharynx. Diffusely enhancing mass with surrounding bony erosion and increased 18-F fludeoxyglucose uptake was found at the nasopharynx, suggesting malignancy. But the cases were finally confirmed as IgG4-related sclerosig disease by punch biopsy and the symtoms improved with glucocorticoid therapy. We report our experiences with a literature review.


Autoimmune; Immunoglobulin G; Nasopharynx; Sclerosing disease
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