Korean J Otorhinolaryngol-Head Neck Surg.  2016 Apr;59(4):287-292. 10.3342/kjorl-hns.2016.59.4.287.

Chronic Obstructive Pulmonary Disease Is Negatively Related with Nasal Polyp in Middle Aged and Elderly Chronic Rhinosinusitis Patients

• Lee MG
• Kim SW
• Yang JH
• Lee JH
• Choi HG

• KMID: 2162261
• DOI: http://doi.org/10.3342/kjorl-hns.2016.59.4.287

Abstract

BACKGROUND AND OBJECTIVES
Chronic obstructive pulmonary disease (COPD) is known to induce chronic rhinosinusitis (CRS). Nasal polyp, which is frequently found in patients with CRS, seems to have close relationship with COPD, but little is known about its relationship with COPD. In this study, we investigated the relationship between COPD and nasal polyp in middle aged and elderly CRS patients.
SUBJECTS AND METHOD
We analyzed the clinical data of 174 patients (age of over 50 years) with CRS. Patients were divided as COPD [forced expiratory volume (FEV1)/forced vital capacity (FVC)<70%, n=30] and non-COPD group (FEV1/FVC≥70%, n=144) according to the pulmonary function test results. Binary logistic regression analysis was used to describe the relationships between clinically relevant factors related to nasal polyp.
RESULTS
On logistic regression analysis, no significant relationship was found between age [adjusted odds ratio (AOR): 1.058, 95% confidence interval for the difference (CI)=0.995-1.126, p=0.073], sex AOR: 0.897, 95% CI=0.366-2.415, p=0.897), smoking (AOR: 0.434, 95% CI=0.154-1.219, p=0.113) and obesity (underweight AOR: 3.833, 95% CI=0.781-18.808, p=0.098, overweight AOR: 5.169, 95% CI=0.996-26.814, p=0.051, obese AOR: 2.911, 95% CI=0.335-25.329, p=0.333) with polyp. However, there was a negative correlation between COPD history and nasal polyp with statistical significance (AOR: 0.288, 95% CI=0.102-0.809, p=0.018).
CONCLUSION
Our findings suggest that patients with COPD are less likely to have nasal polyp than patients without COPD.

Keyword

Aged; Chronic obstructive pulmonary disease; Middle aged; Nasal polyps; Sinusitis

MeSH Terms

Aged*
Humans
Logistic Models
Middle Aged*
Nasal Polyps*
Obesity
Odds Ratio
Overweight
Polyps
Pulmonary Disease, Chronic Obstructive*
Respiratory Function Tests
Sinusitis
Smoke
Smoking
Vital Capacity
Smoke