Korean J Intern Med.  2015 May;30(3):279-293. 10.3904/kjim.2015.30.3.279.

Hard tissue regeneration using bone substitutes: an update on innovations in materials

  • 1Institute of Tissue Regeneration, Soonchunhyang University College of Medicine, Cheonan, Korea. lbt@sch.ac.kr
  • 2Department of Regenerative Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.


Bone is a unique organ composed of mineralized hard tissue, unlike any other body part. The unique manner in which bone can constantly undergo self-remodeling has created interesting clinical approaches to the healing of damaged bone. Healing of large bone defects is achieved using implant materials that gradually integrate with the body after healing is completed. Such strategies require a multidisciplinary approach by material scientists, biological scientists, and clinicians. Development of materials for bone healing and exploration of the interactions thereof with the body are active research areas. In this review, we explore ongoing developments in the creation of materials for regenerating hard tissues.


Bone substitutes; Bone tissue engineering; Bioceramics; Hydrogel; Biopolymers
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