Korean J Otorhinolaryngol-Head Neck Surg.  2016 Mar;59(3):233-237. 10.3342/kjorl-hns.2016.59.3.233.

A Case of Metachronous Human Papilloma Virus-Associated Squamous Cell Carcinomas in Head and Neck

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. chungmk@skku.edu

Abstract

Synchronous or metachronous head and neck cancer is known to occur in up to 20% of patients, negatively affecting long-term prognosis. We experienced a case of metachronous head and neck cancers in a Human papillomavirus (HPV)-positive patient without a history of smoking, initially presenting with as a cancer of unknown primary (CUP), and then with a contralateral tonsil cancer with metastatic lymphadenopathy five years later. This report highlights the clinical usefulness of HPV typing to determine the optimal extent of surgery and the follow-up strategy in CUP.

Keyword

Cancer of unknown primary; Human papillomavirus; Metachronous cancer; Surgery; Tonsil cancer

MeSH Terms

Carcinoma, Squamous Cell*
Follow-Up Studies
Head and Neck Neoplasms
Head*
Humans*
Lymphatic Diseases
Neck*
Papilloma*
Prognosis
Smoke
Smoking
Tonsillar Neoplasms
Smoke
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