Ann Dermatol.  2002 Dec;14(4):195-199. 10.5021/ad.2002.14.4.195.

Tacrolimus ointment: An Open study for Effects on Severe Facial Atopic Dermatitis in Korean

Abstract

BACKGROUND
In recent studies, tacrolimus ointment has been shown to be effective for the treatment of atopic dermatitis with an excellent safety profile.
OBJECTIVE
This study was done to assess the efficacy and side-effects of tacrolimus ointment for the facial atopic dermatitis(AD) in Korean.
PATIENTS AND METHODS
Open-label, non-comparative study with 2 months' follow-up was done to assess the efficacy and safety of tacrolimus ointment (Protopic0ointment 0.1%, Fujisawa, Japan) in moderate to severe facial AD. Patients were instructed to apply it two times daily for 8 weeks. Facial lesions were evaluated at baseline, 4 and 8 weeks of treatment with in-tensity score by investigator.
RESULTS
In comparing of intensity scores and each clinical score at baseline with those of 4 and 8 weeks of treatment, a significant decrease was noticed at all follow-up periods. Burning sense(54.5%) and pruritus(18.2%) were detected.
CONCLUSION
Tacrolimus ointment is effective in treatment of severe facial AD and has tolerable mild adverse effects at the site of application in Korean.

Keyword

Atopic dermatitis; Tacrolimus

MeSH Terms

Burns
Dermatitis, Atopic*
Follow-Up Studies
Humans
Research Personnel
Tacrolimus*
Tacrolimus

Cited by  1 articles

Effect of infosheet for topical tacrolimus 0.1% and its efficacy and compliance in the treatment of atopic dermatitis
Ji Su Han, Woo Jin Lee, Joo Yeon Ko, Joung Soo Kim, Sang Seok Kim, Soo Hong Seo, Bark-Lynn Lew, Ga-Young Lee, Ju Hee Lee, Chang Ook Park, Sang Jai Jang, Hyun Soo Park, Seung Phil Hong, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon, Chong Hyun Won
Allergy Asthma Respir Dis. 2013;1(3):221-226.    doi: 10.4168/aard.2013.1.3.221.

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