Ann Dermatol.  2002 Jun;14(2):63-70. 10.5021/ad.2002.14.2.63.

Whitening Effect of Cosmetics Containing Magnesium L-Ascorbyl-2-Phosphate(VC-PMG, Vitamin C Derivatives) Assessed by Colorimeter

• Park YK
• Park YK
• Chung WS
• Lee H
• Jung SW

• KMID: 2158720
• DOI: http://doi.org/10.5021/ad.2002.14.2.63

Abstract

BACKGROUND
S: An inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG, a stable derivative of ascorbic acid) on melanogenesis has been described. Furthermore, glabridin in licorice is known to have inhibitory effects on melanogenesis and widely used for raw materials for depigmenting agents.
OBJECTIVE
The purposes of this study are to provide objective data by measuring the visual clinical effects of VC-PMG with the colorimeter and to promote the development of de-pigmenting agents.
METHODS
20 volunteers joined the study. With an artificial UVB irradiation, eight tanned areas were made on the inner side of the forearm. During two months, each tanned area was treated with five whitening cosmetics with 3% VC-PMG and increasing concentration of licorice from 0% to 3%. Darkness degree of each area was measured weekly by the colorimeter and the visual assessment.
RESULTS
For all cosmetics, whitening effect was measured by colorimeter and visual as-sessment. The cosmetic containing VC-PMG 3% and licorice 1% had more whitening effect than any other cosmetics of different concentrations. Moreover, VC-PMG 3% alone also had whitening effect in some volunteers.
CONCLUSION
VC-PMG was clinically found to have whitening effect.

Keyword

VC-PMG Whitening Colonmeter

MeSH Terms

Ascorbic Acid*
Darkness
Forearm
Glycyrrhiza
Magnesium*
Triacetoneamine-N-Oxyl
Vitamins*
Volunteers
Ascorbic Acid
Magnesium
Triacetoneamine-N-Oxyl
Vitamins