J Korean Radiol Soc.  2001 Jun;44(6):733-741. 10.3348/jkrs.2001.44.6.733.

Analysis of Signal Intensity Curve on Dynamic Contrast-Enhanced MR Imaging of Postoperative Scars in Rabbits:Comparison of Gadopentetate Dimeglumine and 24-gadolinium-tetraazacy-clododecanetetraacetic acid (DOTA)-dendrimer

Affiliations
  • 1Department of Radiology, Seoul National University College of Medicine and the Institute of Radiation Medicine, SNUMRC.

Abstract

PURPOSE: To compare the enhancement patterns of 24-gadolinium-tetrazacyclodode-cane tetracetic acid (DOTA)-dendrimer (Gadomer-17) with those of gadopentetate dimeglumine (Magnevist) in postoperative scars in rabbits.
MATERIALS AND METHODS
Twelve rabbit thighs with experimentally induced postoperative scars underwent dynamic contrast-enhanced MR imaging with both Gadomer-17 and gadopentetate dimeglumine at a 24-hr interval at one (n = 10), two (n = 8) and three months (n=4) after scar induction. The enhancement and the ratios of lesions at each time point, peak enhancement ratios, and the slope and shape of curves were assessed.
RESULTS
At all time points, enhancement ratios were significantly lower after the injection of Gadomer-17 than with gadopentetate dimeglumine (p<0.05). Peak enhancement ratios were significantly lower with Gadomer-17 (1.29+/-0.15) than with gadopentetate dimeglumine (1.61+/-0.31) (p<0.01). The slope values were 2.99%/min+/-2.72 after Gadomer-17 injection and 8.99%/min+/-7.32 after gadopentetate dimeglumine injection (p<0.01). The enhancement ratio curves showed mostly the plateau pattern with Gadomer-17 (90.9%), while for gadopentetate dimeglumine, the curve pattern was either plateau (50%) or washout (50%). Difference in enhancement characteristics between the two contrast agents were most pronounced for one-month scars.
CONCLUSION
With Gadomer-17, weaker enhancement and the plateau pattern were found in postoperative scars, whereas stronger enhancement and either washout or the plateau pattern were found with gadopentetate dimeglumine.

Keyword

Magnetic resonance (MR), experimental studies; Magnetic resonance (MR), contrast enhancement; Animals
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