Ann Dermatol.  2015 Dec;27(6):759-762. 10.5021/ad.2015.27.6.759.

Cutaneous and Systemic Plasmacytosis Associated with Renal Amyloidosis

Affiliations
  • 1Department of Dermatology, Maryknoll Medical Center, Busan, Korea. heartthrob80@naver.com
  • 2Department of Nephrology, Maryknoll Medical Center, Busan, Korea.
  • 3Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Cutaneous and systemic plasmacytosis (CSP) is a rare disorder of unknown etiology characterized by cutaneous polyclonal plasma cell infiltrates associated with various extracutaneous involvement and polyclonal hypergammaglobulinemia. Here, we report on a 54-year-old male patient with chronic renal insufficiency who presented with disseminated reddish-brown macules and plaques on the face and trunk. In our evaluation, he was found to have lymphadenopathy, polyclonal hypergammaglobulinemia; benign plasma cell infiltration involving the skin, bone marrow, and retroperitoneal area; and renal amyloidosis. To the best of our knowledge, this is the first reported case of CSP associated with renal amyloidosis.

Keyword

Cutaneous and systemic plasmacytosis; Renal amyloidosis

MeSH Terms

Amyloidosis*
Bone Marrow
Humans
Hypergammaglobulinemia
Lymphatic Diseases
Male
Middle Aged
Plasma Cells
Renal Insufficiency, Chronic
Skin

Figure

  • Fig. 1 (A, B) Innumerable disseminated reddish-brown macules and plaques on the face and back.

  • Fig. 2 (A) Dense perivascular and periadnexal mature plasma cells infiltrate in the dermis (H&E, ×40). (B) Monomorphic population of mature plasma cells with hyperchromatic nuclei showing neither atypia nor mitoses (×400).

  • Fig. 3 A computed tomography scan of the abdomen showing diffuse lymphadenopathy along the para-aortic (arrow), aortocaval (arrowhead), both renal hilar, obturator, and inguinal lymph nodes.

  • Fig. 4 (A) Deposition of homogeneous eosinophilic materials (arrows) was seen at the mesangial area and capillary loop of the glomerulus (H&E, ×200). (B) A Congo red-stained section revealing yellow-green birefringence under polarized light (×400).


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