Ann Dermatol.  2012 Feb;24(1):61-65. 10.5021/ad.2012.24.1.61.

Association between IL17A/IL17RA Gene Polymorphisms and Susceptibility to Alopecia Areata in the Korean Population

• Lew BL
• Cho HR
• Haw S
• Kim HJ
• Chung JH
• Sim WY

• KMID: 2156857
• DOI: http://doi.org/10.5021/ad.2012.24.1.61

Abstract

BACKGROUND
Alopecia areata is marked by autoimmune assault on the hair follicle resulting in hair loss. T helper 17 cell subset has important roles in protecting the host against extracellular pathogens, however, also promotes inflammatory pathology in autoimmune disease, and it expresses both interleukin (IL)-17A and IL-17F, which can signal via the IL-17 receptor A.
OBJECTIVE
To investigate the significance of IL17A and IL17RA gene polymorphisms in the susceptibility to alopecia areata.
METHODS
We conducted case-control association study of 238 alopecia areata patients and 270 matched healthy controls. Allele frequency of total 2 single nucleotide polymorphims in the IL17A gene and 4 single nucleotide polymorphims in the IL17RA gene were studied. The statistical analyses were performed according to onset age, the presence of familyhistory, clinical subtypes, and presence of nail involvement or body hair involvement.
RESULTS
One single nucleotide polymorphim (rs879577) of IL17RA gene showed significant difference between alopecia areata patients group and controls group (p= 0.0288). One single nucleotide polymorphim (rs4819554) of IL17RA gene showed significant difference between the early onset and late onset alopecia areata (p=0.0421).
CONCLUSION
IL17RA gene polymorphism might contribute to the increased susceptibility to alopecia areata in Korean population, and IL17RA gene polymorphism may be associated with onset age.

Keyword

Alopecia areata; Interleukin-17A; Interleukin-17 receptors A; Single nucleotide polymorphism

MeSH Terms

Age of Onset
Alopecia
Alopecia Areata
Autoimmune Diseases
Case-Control Studies
Gene Frequency
Hair
Hair Follicle
Humans
Interleukin-17
Interleukins
Nails
Polymorphism, Single Nucleotide
Interleukin-17
Interleukins

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