Ann Dermatol.  2011 Sep;23(Suppl 1):S119-S122. 10.5021/ad.2011.23.S1.S119.

A Case of Familial Cutaneous Collagenoma

• Park MY
• Choi YJ
• Lee JY
• Shin MS
• Ahn JY

• KMID: 2156768
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S119

Abstract

Familial cutaneous collagenoma is a rare hereditary disease that is inherited in an autosomal dominant pattern. It is characterized by early onset of multiple, skin-colored, sometimes hypopigmented cutaneous nodules, which initially show a symmetrical arrangement on the trunk, and later on the neck and upper limbs. We report on a case of a 45-year-old female who presented with multiple oval to round hypopigmented papules measuring 5~15 mm on her trunk. Histopathologically, the lesions showed an increased amount of collagen fibers and decreased, fragmented elastic fibers in the dermis. The skin lesions were diagnosed as familial cutaneous collagenoma and no treatment was administered. To the best of our knowledge, our case is the first reported case of familial cutaneous collagenoma (FCC) in the Korean literature.

Keyword

Collagenoma

MeSH Terms

Collagen
Dermis
Elastic Tissue
Female
Genetic Diseases, Inborn
Humans
Middle Aged
Neck
Skin
Upper Extremity
Collagen

Figure

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  Fig. 1 (A) Multiple 5~15 mm sized oval to round hypopigmented papules and patches on the patient's abdomen, chest, and flank. (B) The magnified clinical feature on abdomen.

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  Fig. 2 Pedigree of the family. Men are represented by squares, women by circles. The solid symbols denote the cases.

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  Fig. 3 (A) Skin biopsy from the lower abdomen revealed slightly homogenized condensed collagen and decreased elastic fibers in the dermis (H&E, ×40). (B) Excessive accumulation of collagen in the dermis (Masson's trichrome stain, ×40). (C) Decreased and fragmented elastic fibers in the dermis (Verhoeff-van Gieson stain, ×40)

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