Ann Dermatol.  2011 May;23(2):198-200. 10.5021/ad.2011.23.2.198.

A Case of Tumor of the Follicular Infundibulum with Sebaceous Differentiation

• Lee DW
• Yang JH
• Lee HM
• Won CH
• Chang S
• Lee MW
• Choi JH
• Moon KC

• KMID: 2156662
• DOI: http://doi.org/10.5021/ad.2011.23.2.198

Abstract

Tumor of the follicular infundibulum (TFI) is an uncommon benign adnexal tumor that usually presents as a solitary keratotic papule on the face or scalp of elderly patients. Histopathologically, it typically manifests as a plate-like fenestrated proliferation of monomorphic pale-staining cells. A 76-year-old male presented with about a 2 cm, well-defined, yellowish to brownish, slightly elevated, twisted and bent, interrupted, cord-like plaque on his left lower abdomen. Microscopic examination revealed a sharply demarcated plate-like proliferation of pale cells localized in the papillary dermis with multiple connections to the overlying epidermis. The histopathological features were compatible with TFI, except for foci of sebaceous differentiation. There has been one previous case report of TFI with sebaceous differentiation in the English medical literature. Herein, we report on a singular case of TFI with sebaceous differentiation.

Keyword

Sebaceous differentiation; Tumor of the follicular infundibulum

MeSH Terms

Abdomen
Aged
Dermis
Epidermis
Humans
Male
Scalp

Figure

• 

  Fig. 1 Gross appearance of the lesion. A 2-cm sized, well-demarcated, yellowish to brownish scaly plaque on the left lower abdomen was observed.

• 

  Fig. 2 Histologic examination of the lesion. (A) A superficial plate-like growth of pale cells in the upper dermis extending parallel to the epidermis with multiple thin connections to the epidermis (H&E, ×40). (B) Pale-staining tumor cells with peripheral palisading (H&E, ×100). (C) Foci of sebaceous differentiation at the base of the tumor (H&E, ×400).

Reference

1. Mehregan AH, Butler JD. A tumor of follicular infundibulum. Report of a case. Arch Dermatol. 1961. 83:924–927.

2. Cribier B, Grosshans E. Tumor of the follicular infundibulum: a clinicopathologic study. J Am Acad Dermatol. 1995. 33:979–984.

3. Mahalingam M, Bhawan J, Finn R, Stefanato CM. Tumor of the follicular infundibulum with sebaceous differentiation. J Cutan Pathol. 2001. 28:314–317.

4. Horn TD, Vennos EM, Bernstein BD, Cooper PH. Multiple tumors of follicular infundibulum with sweat duct differentiation. J Cutan Pathol. 1995. 22:281–287.

5. Ackerman AB, De Viragh PA, Chongchitnant N. Neoplasms with follicular differentiation. 1993. 1st ed. Philadelphia: Lea & Febiger;553–560.

6. McCalmont TH. Bolognia JL, Jorizzo JL, Rapini RP, editors. Adnexal neoplasms. Dermatology. 2008. 2nd ed. St. Louis: Mosby;1700–1701.

7. Kolenik SA 3rd, Bolognia JL, Castiglione FM Jr, Longley BJ. Multiple tumors of the follicular infundibulum. Int J Dermatol. 1996. 35:282–284.

8. Abbas O, Mahalingam M. Tumor of the follicular infundibulum: an epidermal reaction pattern. Am J Dermatopathol. 2009. 31:626–633.

9. Rothko K, Farmer ER, Zeligman I. Superficial epithelioma with sebaceous differentiation. Arch Dermatol. 1980. 116:329–331.

10. Kato N, Ueno H. Superficial epithelioma with sebaceous differentiation. J Dermatol. 1992. 19:190–194.

11. Leboeuf NR, Mahalingam M. Acanthomatous superficial sebaceous hamartoma? A study of six cases with clarification of the nomenclature. J Cutan Pathol. 2007. 34:865–870.