Ann Dermatol.  2009 Nov;21(4):402-405. 10.5021/ad.2009.21.4.402.

Cutaneous Plexiform Schwannomas in a Patient with Neurofibromatosis Type 2

Affiliations
  • 1Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. romio@hanyang.ac.kr

Abstract

Plexiform schwannoma is a rare benign neoplasm of the neural sheath characterized by a multinodular plexiform growth pattern. The tumor usually occurs as an isolated finding, although rare cases have been reported in association with neurofibromatosis type 2 (NF2). A 25-year-old man was admitted for foot drop. He had an asymptomatic skin-colored nodule on his neck that had been present for 10 years. His medical history included local excision of a plexiform schwannoma on his left leg in our dermatology clinic 6 years prior. A histopathological examination of the skin-colored nodule also showed the typical microscopic features of a plexiform schwannoma, including the characteristic Antoni type A areas showing frequent nuclear palisading and Verocay bodies. Magnetic resonance imaging revealed a meningioma and a vestibular schwannoma in the cranium and multiple neurofibromas on the spinal cord. Herein we report a rare case of cutaneous plexiform schwannomas in a patient with NF2.

Keyword

Neurofibromatosis type 2; Plexiform; Schwannoma

MeSH Terms

Adult
Dermatology
Foot
Humans
Leg
Magnetic Resonance Imaging
Meningioma
Neck
Neurilemmoma
Neurofibromatoses
Neurofibromatosis 2
Neuroma, Acoustic
Skull
Spinal Cord

Figure

  • Fig. 1 (A) Skin-colored movable nodule on the right side of the neck, (B) a brown tumor on the left calf.

  • Fig. 2 (A) Multiple lobulated nodules in the dermis (H&E, Scanning view), (B) Antoni type A areas showing frequent nuclear palisading and Verocay bodies (H&E, ×400), (C) tumor nodules strongly positive for S-100 protein (S-100, ×40), (D) tumor nodules negative for neurofilament (Neurofilament, ×40).

  • Fig. 3 MRI view, (A) vestibular schwannoma in the left internal acoustic canal, (B) meningioma involving the vertex of the superior sagittal sinus, (C) multiple neurofibromas from vertebral levels T11 to L4.


Cited by  1 articles

Plexiform Schwannoma with Localized Hypertrichosis
Woo-Il Kim, Tae-Wook Kim, Sung-Min Park, Hyun-Joo Lee, HyunJu Jin, Hyang-Suk You, Woo-Haing Shim, Gun-Wook Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko
Ann Dermatol. 2018;30(4):508-509.    doi: 10.5021/ad.2018.30.4.508.


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