Ann Dermatol.  2009 Nov;21(4):396-398. 10.5021/ad.2009.21.4.396.

Neurocristic Cutaneous Hamartoma of the Scalp

• Kim SK
• Kim YC

• KMID: 2156504
• DOI: http://doi.org/10.5021/ad.2009.21.4.396

Abstract

Neurocristic cutaneous hamartomas (NCHs) result from aberrant development of the neuromesenchyme. In addition to a dermal melanocytic component, these tumors can contain neuro sustentacular and fibrogenic components. The clinical importance of these lesions includes the potential for misdiagnosis as well as the development of malignant melanomas over a poorly described period of time. We present a rare case of NCH of the scalp in a 1-year-old female.

Keyword

Hamartoma; Neurocristic; Scalp

MeSH Terms

Diagnostic Errors
Female
Hamartoma
Humans
Melanoma
Scalp

Figure

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  Fig. 1 3×2 cm blue-gray plaque on the scalp.

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  Fig. 2 (A) Proliferation of nerve-like structures, spindle cells, and melanocytes (H&E, ×100) (inset, wavy spindle cells, ×400). (B) Diffuse S-100 protein staining within the nerve-like structures and pigmented cells (Immunohistochemical staining using the ABC method, ×200). (C) HMB-45 diffusely stained the pigmented cells, however, the area with schwannian differentiation did not stain with HMB-45 (Immunohistochemical staining using the ABC method, ×400). (D) NSE staining within the nerve-like structures (Immunohistochemical staining using the ABC method, ×400).

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