Korean J Med.  2016 Mar;90(3):243-247. 10.3904/kjm.2016.90.3.243.

Acute Lymphoblastic Leukemia Diagnosed in a Patient with Acromegaly

• Oh YS
• Choi MS
• Shin JK
• Kwon HS
• Son JW
• Kim SR
• Yoo SJ

• KMID: 2155940
• DOI: http://doi.org/10.3904/kjm.2016.90.3.243

Abstract

Acromegaly is a rare disorder caused by excessive amounts of growth hormone. The incidence of colorectal, breast, and thyroid carcinomas is increased in acromegaly. However, there have been few reports on hematological malignancies in acromegaly. We describe a patient who developed acute lymphoblastic leukemia during the course of acromegaly. A 35-year-old woman presented in February 2012 with unexplained lactation and amenorrhea for 4 months. Her growth hormone level was 12.6 microg/L, insulin-like growth factor 1 592.26 ng/mL, and prolactin 242 microg/L. A pituitary macroadenoma secreting GH and prolactin causing acromegaly was diagnosed. Considering her fertility, the dopamine agonist cabergoline 0.5 mg was administered in March 2012. In February 2014, she presented with cytopenia (hemoglobin 12.2 g/dL, white cell count 2.69 x 10(9)/L, platelets 39 x 10(9)/L) and hepatosplenomegaly. A bone marrow examination showed acute B cell lymphoblastic leukemia. She underwent chemotherapy and bone marrow transplantation. A follow-up bone marrow biopsy showed remission.

Keyword

Acromegaly; Precursor cell lymphoblastic leukemia-lymphoma; Insulin-like growth factor I

MeSH Terms

Acromegaly*
Adult
Amenorrhea
Biopsy
Bone Marrow
Bone Marrow Examination
Bone Marrow Transplantation
Breast
Cell Count
Dopamine Agonists
Drug Therapy
Female
Fertility
Follow-Up Studies
Growth Hormone
Hematologic Neoplasms
Humans
Incidence
Insulin-Like Growth Factor I
Lactation
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Prolactin
Thyroid Neoplasms
Dopamine Agonists
Growth Hormone
Insulin-Like Growth Factor I
Prolactin