Clin Exp Vaccine Res.  2016 Jan;5(1):83-87. 10.7774/cevr.2016.5.1.83.

Novel foot-and-mouth disease virus in Korea, July-August 2014

Affiliations
  • 1Animal and Plant Quarantine Agency, Anyang, Korea. parkjhvet@korea.kr

Abstract

Despite nation-wide immunization with O, A, and Asia 1 type vaccines in Republic of Korea, foot-and-mouth disease type O occurred again in July 2014 after three years and three months. This virus was a Mya-98 strain of the Southeast Asian topotype and was most similar to the identified type that circulated in East Asia in 2014. This was new virus with the deletion of 23 amino acids in 3A/3B1 region and low pathogenic property.

Keyword

Foot-and-mouth disease; Sequence deletion; Vaccination; Korea

MeSH Terms

Amino Acids
Animals
Asia
Asian Continental Ancestry Group
Far East
Foot-and-Mouth Disease Virus*
Foot-and-Mouth Disease*
Humans
Immunization
Korea*
Republic of Korea
Sequence Deletion
Vaccination
Vaccines
Amino Acids
Vaccines

Figure

  • Fig. 1 Foot-and-mouth disease (FMD) outbreak in South Korea, July 2014 and mean rate of FMD antibody prevalence in each provinces. (A) The region of three FMD cases in Gyeongbuk (GB), Gyeongnam (GN) provinces and antibody prevalence of cattle and pigs in outbreak time point. (B) Monthly FMD antibody prevalence in Korea. GG, Gyeonggi; GW, Gangwon; CN, Chungnam; CB, Chungbuk; JN, Jeonnam; JB, Jeonbuk; JJ, Jeju.

  • Fig. 2 Phylogenetic tree and genetic analysis using the VP1 genes of foot-and-mouth disease viruses (FMDVs) identified in South Korea and Asian countries during foot-and-mouth disease (FMD) outbreaks in the same periods. (A) A phylogenetic tree was inferred using the neighbor-joining method. The black dots represent cases of FMD reported in Korea, July-August 2014. The percentage of the replicate tree, in which the associated taxa clustered together in the bootstrap test (1,000 replicates), is shown next to the branches. The analysis was conducted using MEGA 6. (B) Deletion of 23 amino acids in 3A/3B region of FMDV occurred in Korea. Rectangle box represents the deleted region in 3A/3B region. Arabic numbers show nucleotide position of O1 Manisa strain (AY593823).

  • Fig. 3 Pathogenesis and transmission after virus challenge and contact or vaccination in pigs. (A) Clinical score, viremia, and virus excretion during 10 days post-infection (vaccinated animals was inoculated with commercial trivalent vaccine before 5 days of contact challenge). (B) Kinetics of virus neutralizing (VN) antibody titers against O/Andong/SKR/2010 and structural protein (SP) enzyme-linked immunosorbent assay (ELISA) antibody for type O virus after challenge and contact.


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New foot-and-mouth disease vaccine, O JC-R, induce complete protection to pigs against SEA topotype viruses occurred in South Korea, 2014–2015
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J Vet Sci. 2019;20(4):.    doi: 10.4142/jvs.2019.20.e42.


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