Clin Exp Vaccine Res.  2016 Jan;5(1):12-18. 10.7774/cevr.2016.5.1.12.

Recent vaccine technology in industrial animals

• Kim H
• Lee YK
• Kang SC
• Han BK
• Choi KM

• KMID: 2152692
• DOI: http://doi.org/10.7774/cevr.2016.5.1.12

Abstract

Various new technologies have been applied for developing vaccines against various animal diseases. Virus-like particle (VLP) vaccine technology was used for manufacturing the porcine circovirus type 2 and RNA particle vaccines based on an alphavirus vector for porcine epidemic diarrhea (PED). Although VLP is classified as a killed-virus vaccine, because its structure is similar to the original virus, it can induce long-term and cell-mediated immunity. The RNA particle vaccine used a Venezuela equine encephalitis (VEE) virus gene as a vector. The VEE virus partial gene can be substituted with the PED virus spike gene. Recombinant vaccines can be produced by substitution of the target gene in the VEE vector. Both of these new vaccine technologies made it possible to control the infectious disease efficiently in a relatively short time.

Keyword

Vaccines; Virus-like particle vaccines; Porcine circovirus; Venezuelan equine encephalitis virus; Porcine epidemic diarrhea virus

MeSH Terms

Alphavirus
Animal Diseases
Animals*
Circovirus
Communicable Diseases
Diarrhea
Encephalitis Virus, Venezuelan Equine
Encephalomyelitis, Equine
Immunity, Cellular
Porcine epidemic diarrhea virus
RNA
Vaccines
Vaccines, Synthetic
Vaccines, Virus-Like Particle
Venezuela
RNA
Vaccines
Vaccines, Synthetic
Vaccines, Virus-Like Particle