Immune Netw.  2015 Feb;15(1):27-36. 10.4110/in.2015.15.1.27.

Protection Against Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Enteritidis Infection in Layer Chickens Conferred by a Live Attenuated Salmonella Typhimurium Strain

Affiliations
  • 1College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Korea. johnhlee@chonbuk.ac.kr

Abstract

In the present study, we investigated the protection conferred by a live attenuated Salmonella enterica serovar Typhimurium (ST) strain against Salmonella Typhimurium, Salmonella Gallinarum (SG), and Salmonella Enteritidis (SE) infection in layer chickens. Birds were orally primed with the attenuated ST strain at 7 days of age and then boosted at 4 weeks post prime immunization (PPI). Sequential monitoring of plasma IgG and mucosal secretory IgA (sIgA) levels revealed that inoculation with ST induced a significant antibody response to antigens against ST, SE, and SG. Moreover, significant lymphoproliferative responses to the 3 Salmonella serovars were observed in the immunized group. We also investigated protection against virulent ST, SE, and SG strain challenge. Upon virulent SG challenge, the immunized group showed significantly reduced mortality compared to the non-immunized group. The reduced persistence of the virulent ST and SE challenge strains in the liver, spleen, and cecal tissues of the immunized group suggests that immunization with the attenuated ST strain may not only protect against ST infection but can also confer cross protection against SE and SG infection.

Keyword

Salmonella; Vaccine; Cross immunity; Protection; Chickens

MeSH Terms

Antibody Formation
Birds
Chickens*
Cross Protection
Immunization
Immunoglobulin A, Secretory
Immunoglobulin G
Liver
Mortality
Plasma
Salmonella enterica
Salmonella enteritidis*
Salmonella typhimurium*
Salmonella*
Spleen
Immunoglobulin A, Secretory
Immunoglobulin G
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