Immune Netw.  2010 Aug;10(4):115-119. 10.4110/in.2010.10.4.115.

Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse

Affiliations
  • 1Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea. kimmy@ssu.ac.kr

Abstract

Lymphoid tissue inducer (LTi) cells have been characterized in mouse as a key cell when secondary lymphoid tissues are organized during development and memory T cells are formed after birth. In addition to their involvement in adaptive immune responses, recent studies show that they contribute to innate immune responses by producing large amount of interleukin (IL)-22 against microbial attack. Here, we compare IL-22-producing LTi and LTi-like cells in human and mouse and discuss their heterogeneity in different tissues.

Keyword

LTi; OX40L; IL-22; NK-22

MeSH Terms

Animals
Humans
Immunity, Innate
Interleukins
Lymphoid Tissue
Memory
Mice
Parturition
Population Characteristics
T-Lymphocytes
Interleukins

Figure

  • Figure 1 Correlation between the gene expression patterns of human and mouse cell populations. (A) Mouse splenic Th1 primed cells in vitro for 6 days in the presence of IL-4 and anti-IL-12 and human tonsilar CD45RO+ memory CD4 T cells. (B) Mouse splenic B cells and human tonsilar B cells. (C) Mouse splenic CD11c+ dendritic cells (DC) and human lymph node CD11c+ DC. (D-F) Mouse splenic LTi cells and human LTi cells isolated from spleen (D), lymph node (E), and tonsil (F). Over 0.01% expression of individual mRNAs of β-actin signals were plotted. X- and Y- axes show mRNA expression levels relative to the β-actin signal (β-actin signal=100%, log scale). Each plot compares two cell types, one on each axis (as labeled). CC=correlation coefficient. Analyzed 90 genes are: LT-α, TNF-α, LT-β, OX40L, CD40L, FASL, CD70, CD30L, 4-1BBL, TRANCE, TWEAK, APRIL, BAFF, LIGHT, TL1, TNFR1, TNFR2, LTβR, OX40, CD40, FAS, CD30, 4-1BB, RANK, TWEAKR, BAFFR, HVEM, GITR, DR3, CCR7, CXCR3, CXCR5, Bcl-2, Bcl-6, Bcl-XL, ROR-γ, GATA3, Foxp3, Myd-88, TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, IL-1α, IL-1 β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, TSLP, IL-9, IL-10, IL-12p35, IL-12p40, IL-13, IL-15, IL-18, IFN-α1, IFN-β, IFN-γ, TGF-β1, IL-2Rα, IL-2Rβ, IL-2Rγ, IL-4Rα, IL-7Rα, IL-10Rα, IL-10Rβ, IL-12Rβ1, IL-12Rβ2, IFNγR1, IFNγR2, CD80, CD86, DC-SIGN, CathepsinS, integrin alpha x, CTLA4, ICOS, ICOSL, β-2m, T-bet, CD4, CD74, perforin, and granzymeB.


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