Ann Pediatr Endocrinol Metab.  2015 Sep;20(3):166-169. 10.6065/apem.2015.20.3.166.

Hypotonic hyponatremia by primary polydipsia caused brain death in a 10-year-old boy

Affiliations
  • 1Department of Pediatrics, Severance Children's Hospital, Institute of Endocrinology, Yonsei University College of Medicine, Seoul, Korea. armea@yuhs.ac
  • 2Sowha Children's Hospital, Seoul, Korea.

Abstract

Hypotonic hyponatremia by primary polydipsia can cause severe neurologic complications due to cerebral edema. A 10-year-and-4-month-old boy with a psychiatric history of intellectual disability and behavioral disorders who presented with chief complaints of seizure and mental change showed severe hypotonic hyponatremia with low urine osmolality (serum sodium, 101 mmol/L; serum osmolality, 215 mOsm/kg; urine osmolality, 108 mOsm/kg). The patient had been polydipsic for a few months prior, and this had been worse in the previous few days. A diagnosis of hypotonic hyponatremia caused by primary polydipsia was made. The patient was in a coma, and developed respiratory arrest and became brain death shortly after admission, despite the treatment. The initial brain magnetic resonance imaging showed severe brain swelling with tonsillar and uncal herniation, and the patient was declared as brain death. It has been reported that antidiuretic hormone suppression is inadequate in patients with chronic polydipsia, and that this inadequate suppression of antidiuretic hormone is aggravated in patients with acute psychosis. Therefore, hyponatremia by primary polydipsia, although it is rare, can cause serious and life-threatening neurologic complications.

Keyword

Hyponatremia; Psychogenic polydipsia; Water intoxication

MeSH Terms

Brain Death*
Brain Edema
Brain*
Child*
Coma
Diagnosis
Humans
Hyponatremia*
Intellectual Disability
Magnetic Resonance Imaging
Male*
Osmolar Concentration
Polydipsia
Polydipsia, Psychogenic*
Psychotic Disorders
Seizures
Sodium
Water Intoxication
Sodium

Figure

  • Fig. 1 Brain magnetic resonance imaging showing severe brain swelling with tonsillar and uncal herniation (asterisk).


Reference

1. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000; 342:1581–1589. PMID: 10824078.
Article
2. Berl T. Treating hyponatremia: damned if we do and damned if we don't. Kidney Int. 1990; 37:1006–1018. PMID: 2179612.
Article
3. de Leon J, Verghese C, Tracy JI, Josiassen RC, Simpson GM. Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol Psychiatry. 1994; 35:408–419. PMID: 8018788.
Article
4. Vieweg WV, Leadbetter RA. Polydipsia-hyponatraemia syndrome : epidemiology, clinical features and treatment. CNS Drugs. 1997; 7:121–138. PMID: 23338131.
5. Riggs AT, Dysken MW, Kim SW, Opsahl JA. A review of disorders of water homeostasis in psychiatric patients. Psychosomatics. 1991; 32:133–148. PMID: 2027935.
Article
6. Snyder SH. Drug and neurotransmitter receptors in the brain. Science. 1984; 224:22–31. PMID: 6322304.
Article
7. Illowsky BP, Kirch DG. Polydipsia and hyponatremia in psychiatric patients. Am J Psychiatry. 1988; 145:675–683. PMID: 3285701.
Article
8. Luchins DJ. A possible role of hippocampal dysfunction in schizophrenic symptomatology. Biol Psychiatry. 1990; 28:87–91. PMID: 2378923.
Article
9. Hariprasad MK, Eisinger RP, Nadler IM, Padmanabhan CS, Nidus BD. Hyponatremia in psychogenic polydipsia. Arch Intern Med. 1980; 140:1639–1642. PMID: 7458496.
Article
10. Goldman MB, Luchins DJ, Robertson GL. Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia. N Engl J Med. 1988; 318:397–403. PMID: 3340117.
Article
11. Fiser DH, Jimenez JF, Wrape V, Woody R. Diabetes insipidus in children with brain death. Crit Care Med. 1987; 15:551–553. PMID: 3568723.
Article
12. Emsley R, Potgieter A, Taljaard F, Joubert G, Gledhill R. Water excretion and plasma vasopressin in psychotic disorders. Am J Psychiatry. 1989; 146:250–253. PMID: 2912268.
Article
13. Waller G, Hyde CE, Thomas CS. A "biofeedback" approach to the treatment of chronic polydipsia. J Behav Ther Exp Psychiatry. 1993; 24:255–259. PMID: 8188850.
Article
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