Transl Clin Pharmacol.  2015 Jun;23(1):8-14. 10.12793/tcp.2015.23.1.8.

Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics

• Choi K
• Yim DS

• KMID: 2148853
• DOI: http://doi.org/10.12793/tcp.2015.23.1.8

Abstract

The maximum likelihood estimator is the point estimator of the top priority in statistical data analysis because of its optimum properties for large sample size. While the maximum likelihood estimator is widely used, it has been an abstruse subject for pharmacometricians without statitics bagkround because of high dimensional calculus and asymptotic theories. This tutorial provides a general and brief introduction to the maximum likelihood estimator and its related caluculus for non-statisticians.

MeSH Terms

Calculi
Data Interpretation, Statistical
Sample Size

Reference

References

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