J Korean Ophthalmol Soc.  2015 Jul;56(7):1065-1074. 10.3341/jkos.2015.56.7.1065.

Analysis of Choroidal Thickness Measured Using RTVue and Associated Factors in Open-Angle Glaucoma

• Jin SW
• Choi WS
• Seo HR
• Rho SS
• Rho SH

• KMID: 2148807
• DOI: http://doi.org/10.3341/jkos.2015.56.7.1065

Abstract

PURPOSE
To compare the macular choroidal thickness, ganglion cell complex thickness, peripapillary choroidal thickness and retinal nerve fiber layer thickness among normal, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients using RTVue (Fourier-domain optical coherence tomography; Optovue, Fremont, CA, USA).
METHODS
A retrospective analysis of 32 normal controls, 32 POAG and 52 NTG patients was performed. Choroidal thickness, ganglion cell complex thickness and retinal nerve fiber layer thickness were compared among normal controls, POAG and NTG subjects. Additionally, the factors influencing choroidal thickness (age, axial length, spherical equivalent, central corneal thickness, mean deviation, nocturnal dip, blood pressure variability) were analyzed.
RESULTS
A total of 32 normal controls, 32 POAG and 52 NTG patients were enrolled in this study. Macular and peripapillary choroidal thicknesses were significantly thinner in the NTG patients. In NTG subjects, the significant influencing factors associated with macular and peripapillary choroidal thicknesses were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant influencing factors associated with macular and peripapillary choroidal thicknesses were age and axial length.
CONCLUSIONS
Choroidal thickness was significantly thinner in NTG patients compared with normal controls and POAG patients. Factors influencing choroidal thickness in NTG patients were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant factors influencing choroidal thickness were age and axial length.

Keyword

Blood pressure variability; Choroidal thickness; Nocturnal dip; RTVue

MeSH Terms

Blood Pressure
Choroid*
Ganglion Cysts
Glaucoma, Open-Angle*
Humans
Low Tension Glaucoma
Nerve Fibers
Retinaldehyde
Retrospective Studies
Tomography, Optical Coherence
Retinaldehyde

Figure

• 

  Figure 1 . Choroidal thickness of the macula. The image was acquired using the RTVue FD-OCT. The macular thickness is meas-ured horizontally at 3 points: fovea, 750 μ m nasal from the fovea, 750 μ m temporal from the fovea (double headed white arrow: measurements line between the retinal pigment epithelium and sclera at the fovea). FD-OCT = Fourier domain-optical coherence tomography.

• 

  Figure 2. Choroidal thickness of the peripapillary area. The image was acquired using the RTVue FD-OCT. The peripapillary thick-ness is measured at 8 points around the optic disc. FD-OCT = Fourier domain-optical coherence tomography.

• 

  Figure 3. 24-hour ambulatory blood pressure monitoring (24-hr ABPM). (A) 24-hr ABPM (TONOPORT V. GM Medical System, Freiburg, Germany). (B) A picture of patient who is undergoing 24-hr ABPM. (C) Printouts from the commercially available 24-hr ABPM. syst. = systolic blood pressure; diast = diastolic blood pressure.

Reference

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