Korean J Anesthesiol.  2015 Jun;68(3):261-266. 10.4097/kjae.2015.68.3.261.

A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang Univertisy College of Medicine, Cheonan, Korea. ksjsk@schca.ac.kr
  • 2Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang Univertisy College of Medicine, Cheonan, Korea.

Abstract

BACKGROUND
We planned to compare the effect of intravenous oxycodone and fentanyl on post-operative pain after laparoscopic hysterectomy.
METHODS
We examined 60 patients were randomized to postoperative pain treatment with either oxycodone (n = 30, Group O) or fentanyl (n = 30, Group F). The patients received 10 mg oxycodone/100 microg fentanyl with ketorolac 30 mg before the end of anesthesia and then continued with patient-controlled analgesia for 48 h postoperatively.
RESULTS
The accumulated oxycodone consumption was less than fentanyl during 8, 24 and 48 h postoperatively. Numeric rating score of Group O showed significantly lower than that of Group F during 30 min, 2, 4, 8 and 24 h postoperatively. The incidences of adverse reactions were similar in the two groups, though the incidence of nausea was higher in the Group O during the 24 and 48 h postoperative period.
CONCLUSIONS
Oxycodone IV-PCA was more advantageous than fentanyl IV-PCA for laparoscopic hysterectomy in view of accumulated oxycodone consumption, pain control and cost beneficial effect. However, patient satisfaction was not good in the group O compared to group F.

Keyword

Fentanyl; Oxycodone; Postoperative pain
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