Clin Endosc.  2015 Sep;48(5):405-410. 10.5946/ce.2015.48.5.405.

Factors for Endoscopic Submucosal Dissection in Early Colorectal Neoplasms: A Single Center Clinical Experience in China

• He YQ
• Wang X
• Li AQ
• Yang L
• Zhang J
• Kang Q
• Tang S
• Jin P
• Sheng JQ

• KMID: 2148552
• DOI: http://doi.org/10.5946/ce.2015.48.5.405

Abstract

BACKGROUND/AIMS
Early colorectal (CR) neoplasm can be cured by endoscopic submucosal dissection (ESD), but clinical experience and factors associated with complications from ESD for CR neoplasms in China have not been reported.
METHODS
Seventy-eight cases of early CR neoplasm treated with endoscopic resection performed between December 2012 and December 2013 at Beijing Military General Hospital were included. Factors associated with ESD complications and procedure times were evaluated.
RESULTS
The en bloc resection rate was 88.5% (69/78), tumor size was 32.1+/-10.7 mm, and procedure time was 71.8+/-49.5 minutes. The major complication was perforation, which occurred in 8.97% of the ESD procedures. Multivariate logistic regression analysis indicated that only tumor size (p=0.022) was associated with ESD perforation. Tumor size (p<0.001) and the non-lifting sign (p=0.017) were independent factors for procedure time, and procedure time (p=0.016) was a key factor for en bloc resection. After a median 10 months (range, 4 to 16) of follow-up, no patients had local recurrence.
CONCLUSIONS
This study indicated that ESD is an applicable method for large early CR neoplasm in the colon and rectum. Tumor size and the non-lifting sign might be considerable factors for increased complication rate and procedural time of ESD.

Keyword

Endoscopic submucosal dissection; Early colorectal neoplasms; Complications; Procedure time

MeSH Terms

China*
Colon
Colorectal Neoplasms*
Follow-Up Studies
Hospitals, General
Humans
Logistic Models
Military Personnel
Rectum
Recurrence

Figure

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  Fig. 1 (A) Laterally spreading non-granular type tumor in the cecum. (B) A narrow-band image view. (C) Submucosal injection and cutting using Dual-knife. (D) Artificial ulcer after endoscopic submucosal dissection.

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