Korean J Clin Microbiol.  1999 Mar;2(1):64-70.

Antimicrobial Resistance and Serotypes in the Clinical Isolates of Group B Streptococci

• Uh Y
• Jang IH
• Hwang GY
• Yoon KJ

Abstract

BACKGROUND: This study is designed to provide data on the trend of resistance by year of isolation in the clinical isolates of group B streptococci(GBS) during recent eight years and to elucidate the relationship between serotypes and antimicrobial resistance patterns.
METHODS
The minimal inhibitory concentrations (MIC) of seven antimicrobial agents and serotypes for 150 strains of GBS isolated from clinical specimens between 1990 and 1997 were investigated.
RESULTS
The resistance rate of 150 clinical isolates of GBS were 20.0% to clindamycin, 16.0% to erythromycin, 4.0% to chloramphenicol, and 95.3% to tetracycline. None was resistant to penicillin, ceftriaxone, or vancomycin. Of the 24 isolates resistant to erythromycin, 20 (83.3%) were resistant to clindamycin. Resistance rates of erythromycin according to serotypes in decreasing order were 69.2% (V), 23.2% (III), and 3.5% (Ib). All serotypes Ia and II were susceptible to erythromycin and clindamycin.
CONCLUSIONS
Striking emergence of resistant strains to erythromycin and clindamycin in our clinical isolates of GBS was mainly due to sudden increase of serotype V and III which shows multi-drug resistance phenotype.

Keyword

Group B streptococci (GBS); Antimicrobial susceptibility; Erythromycin resistance; Clindamycin resistance; Serotype

MeSH Terms

Anti-Infective Agents
Ceftriaxone
Chloramphenicol
Clindamycin
Drug Resistance, Multiple
Erythromycin
Penicillins
Phenotype
Strikes, Employee
Tetracycline
Vancomycin
Anti-Infective Agents
Ceftriaxone
Chloramphenicol
Clindamycin
Erythromycin
Penicillins
Tetracycline
Vancomycin