J Korean Soc Plast Reconstr Surg.  2003 Jan;30(1):101-104.

A Patient with Xeroderma Pigmentosum Developing Radioresistant Basal Cell Epithelioma

• Son WI
• Byeon JH

Abstract

Xeroderma pigmentosum is rare autosomal recessive disease, characterized by extreme sensitivity to ultraviolet light and leading to development of multiple malignant skin tumors. Among multiple malignant skin tumors, basal cell carcinoma and squamous cell carcinoma are common. Treatments of xeroderma pigmentosum are palliative or radiation treatment, but surgical resection is necessary if xeroderma pigmentosum is transited to malignant skin tumors. We report a case of a 32-years-old female xeroderma pigmentosum patient, who developed radiation resistant basal cell carcinoma on right alar nasi. Radiaton theraphy(300cGy, fractions: 10, total dose: 3000cGy) was not effective, so surgical excision and local skin flap coverage was made and no specific wound complications occurred. During 11 months follow-up period, no evidence of recurrence was found.

Keyword

Xeroderma pigmentosum; Radiation-resistant basal cell carcinoma

MeSH Terms

Carcinoma, Basal Cell*
Carcinoma, Squamous Cell
Female
Follow-Up Studies
Humans
Ichthyosis*
Recurrence
Skin
Ultraviolet Rays
Wounds and Injuries
Xeroderma Pigmentosum*