Korean J Hematol.  2002 Nov;37(4):282-286.

Report of Two Patients with Severe Aplastic Anemia Who Showed Trilineage Hematologic Response to Low-dose Erythropoietin

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University, School of Medicine, Daegu, Korea. sksohn@knu.ac.kr
  • 2Cancer Research Institute, Kyungpook National University, School of Medicine, Daegu, Korea.

Abstract

Aplastic anemia is characterized by multilineage bone marrow failure resulting in pancytopenia. There is no effective therapy for patients with severe aplastic anemia who were refractory to immunosuppresive therapy including antithymocyte globulin (ATG) or relapsed after allogeneic bone marrow transplantation. We report hereby that two patients with severe aplastic anemia who were relapsed after immu-nosuppresive therapy with ATG and cyclosporine A were successfully treated with low dose erythropoietin. Observed trilineage hematologic response was dependent on low dose erythropoietin therapy.

Keyword

Aplastic anemia; Erythropoietin; Trilineage response

MeSH Terms

Anemia, Aplastic*
Antilymphocyte Serum
Bone Marrow
Bone Marrow Transplantation
Cyclosporine
Erythropoietin*
Humans
Pancytopenia
Antilymphocyte Serum
Cyclosporine
Erythropoietin
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