Korean J Med.  2007 Sep;73(3):243-250.

Antiretroviral drug resistance among drug-naive HIV-1 infected patients

• Kim SR
• Rheu EK
• Seol YM
• Cha DH
• Lee SJ
• Yoon YK
• Park SM
• Kim HH
• Rheu HS
• Ahn SC
• Lee SH
• Kwak IS
• Cho GJ

Abstract

BACKGROUND: The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance mutations in drug-naive patients in Korea.
METHODS
Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations in the reverse transcriptase, including revertant mutations at codon 215.
RESULTS
The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and 4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation in NNRTI as well as in the PI region.
CONCLUSIONS
The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in Korean patients.

Keyword

HIV; Antiretroviral agent; Drug resistance

MeSH Terms

Cell Count
Codon
Drug Resistance*
HIV
HIV-1*
Humans
Korea
Male
Plasma
Prevalence
RNA
RNA-Directed DNA Polymerase
Codon
RNA
RNA-Directed DNA Polymerase