J Korean Pediatr Soc.  1994 Jan;37(1):122-128.

Two Cases of Pseudohypoaldosteronism Type I

Abstract

Pseudohypoaldosteronism type 1 is a genetic renal tubular disease of salt wasting, presenting in young infants. Tubular unresponsiveness to elevated endogenous and exogenous aldosterone is the suggested pathogenetic mechanism. Oral sodium chloride supplementation relieve the clinical symptoms and electrolyte distrubances. We experienced 2 cases of PHA type 1 in 38-day and 45-day old male infants who were presented with failure to thrive, vomiting and/or dehydration. Laboratory data showed hyponatremia, hyperkalemia, hypochloremia and metabolic acidosis. Renal and adrenal functions were normal. Plasma renin activity and plasma aldosterone concentration were markedly elevated. Under the diagnosis of pseudohypoaldosteronism type 1, oral supplementation of NaCl and/or kayexalate improved the clinical states of the patients.


MeSH Terms

Acidosis
Aldosterone
Dehydration
Diagnosis
Failure to Thrive
Humans
Hyperkalemia
Hyponatremia
Infant
Male
Plasma
Pseudohypoaldosteronism*
Renin
Sodium Chloride
Vomiting
Aldosterone
Renin
Sodium Chloride
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