J Korean Pediatr Soc.  1997 Apr;40(4):578-583.

A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome

• Kye NY
• Lee KH
• Cha JK
• Yoon HS
• Song WK

Abstract

We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein III a receptor. On third hospital day, the patient expired due to DIC and pulmonary hemorrhage. Authors report the case with review of literature.

Keyword

Congenital acute megakaryoblastic leukemia; Down syndrome

MeSH Terms

Biopsy
Blood Platelets
Bone Marrow
Dacarbazine
Down Syndrome*
Glycoproteins
Hemorrhage
Humans
Leukemia, Megakaryoblastic, Acute*
Megakaryocyte Progenitor Cells
Primary Myelofibrosis
Dacarbazine
Glycoproteins