Korean J Occup Environ Med.  1990 Feb;2(1):75-83.

A Study on the Urinary Metabolites and Sister Chromatid Exchanges of Peripheral Lymphocytes in Workers Exposed to the Organic Solvents

  • 1Department of Preventive Medicine and Public Health, College of Medicine, Busan National University, Korea.
  • 2Masan Indnstried Health Center. Korean Industrial Health Association, Korea.


In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaliiate the effect of organic solvents on Lhe health in industrial workers, the authors Studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocyces from 90 female workers espoxed to organic solvents .and 20 lion-exposed female workers. The results obtained were as follows: 1. The frequency of sister chromatid exchanges in peripheral iympnocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 coatiol subiect. 2. The frequency of sister chromatid exchanges was significantly Increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chrornatid exchanges by carriera of the exposed workers. 4. The correlation between the frequency of sister chromatid exchanges and urinary hippuric acid was significant with the coefficient of 0.5902 showing Y=1.867X+15.188 in which Y indicate the frequency of sister chromatid exchanges per cell and X indicate the urinary hippuric acid concentration by g/l.


Sisier Chromatid Exchanges; Organic Solvents
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