Nutr Res Pract.  2008 Dec;2(4):227-233. 10.4162/nrp.2008.2.4.227.

Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice

• Park SH
• Park TS
• Cha YS

• KMID: 2139196
• DOI: http://doi.org/10.4162/nrp.2008.2.4.227

Abstract

The aim of the present study was to assess the anti-obesity effects of grape seed extract (GSE) supplement in C57BL/6J mice. Thirty mice were divided into three groups; normal diet control group (ND), high fat diet control group (HD) and high fat diet plus grape seed extract supplemented group (HD+GSE). Results were as follows: 1. GSE supplement reduced the weight gain in mice fed high fat diets; epididymal and back fat weights were lower compared to non-supplemented HD group. 2. Blood lipid concentrations were lower in the HD+GSE group than in the HD group. Serum HDL-C concentrations were higher in the HD+GSE group compared with the other groups. 3. The concentrations of acid-insoluble acylcarnitines (AIAC) in serum and liver were higher in the HD+GSE group than in the HD group. 4. GSE supplementation increased mRNA levels of lipolytic genes such as carnitine palmitoyltransferase-1 (CPT-1) and decreased mRNA levels of lipogenic genes such as acetyl CoA carboxylase (ACC). These findings suggest that grape seed extract supplements in high fat diet might normalize body weight, epididymal and back fat weights, lipid concentrations, and carnitine levels through controlling lipid metabolism.

Keyword

Grape seed extract; body weight; lipid concentrations; carnitine; gene expression

MeSH Terms

Acetyl-CoA Carboxylase
Animals
Body Weight
Carnitine
Diet
Diet, High-Fat
Gene Expression
Grape Seed Extract
Lipid Metabolism
Liver
Mice
Obesity
RNA, Messenger
Vitis
Weight Gain
Weights and Measures
Acetyl-CoA Carboxylase
Carnitine
Grape Seed Extract
RNA, Messenger