Yeungnam Univ J Med.  2015 Jun;32(1):1-7. 10.12701/yujm.2015.32.1.1.

Cellular origin of liver cancer stem cells

Affiliations
  • 1Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine, Goyang, Korea. dreundavis@gmail.com

Abstract

Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.

Keyword

Stem cells; Liver cancer stem cells; Hepatocellular carcinoma

MeSH Terms

Carcinoma, Hepatocellular
Liver
Liver Neoplasms*
Neoplasm Metastasis
Neoplastic Stem Cells
Stem Cells*
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