J Korean Med Assoc.  2004 May;47(5):473-478. 10.5124/jkma.2004.47.5.473.

Anti-viral Treatment of Chronic Hepatitis B

Affiliations
  • 1Department of Internal Medicine, Division of Gastroenterology, University of Ulsan College of Medicine, Asan medical Center, Korea. djsuh@amc.soul.kr

Abstract

Patients with chronic hepatitis B virus (HBV) infection are at risk for development of liver cirrhosis and hepatocellular carcinoma. The goal of antiviral therapy for chronic hepatitis B is the permanent suppression of HBV replication; loss of HBV DNA and HBeAg seroconversion. Three antiviral drugsinterferon, lamivudine and adefovir dipivoxil-are avilable now. Although they were proven to have suppressive effects on HBV replication, their antiviral effects are not satisfactory yet and durability of response is low. Emergence of drug resistant mutants is troublesome in lamivudinr therapy. Expense of drugs is another problem for long-term antiviral treatment. Development of new drugs which have stronger and durable antiviral effects and combination therapy with several antiviral drugs to reduce drug resistant mutants are anticipated.

Keyword

Chronic hepatitis B; nterferon; Lamivudine; Adefovir dipivoxil

MeSH Terms

Antiviral Agents
Carcinoma, Hepatocellular
DNA
Hepatitis B e Antigens
Hepatitis B, Chronic*
Hepatitis, Chronic*
Humans
Lamivudine
Liver Cirrhosis
Pheniramine
Antiviral Agents
DNA
Hepatitis B e Antigens
Lamivudine
Pheniramine

Figure

  • Figure 1


Reference

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