J Korean Diabetes.  2011 Jun;12(2):104-108. 10.4093/jkd.2011.12.2.104.

Vitamin D and Diabetes

• Ju D

• KMID: 2137331
• DOI: http://doi.org/10.4093/jkd.2011.12.2.104

Abstract

Epidemiologic evidence suggests that vitamin D status, as assessed by serum 25-hydroxyvitamin D levels, is associated with increased risk for diabetes, and that adequate intake of vitamin D may prevent or delay the onset of diabetes. Many individuals with diabetes have decreased levels of vitamin D, and lack of vitamin D may be associated with hyperglycemia, increased hemoglobin A1c, insulin resistance, and progression of diabetes. Optimal vitamin D status is needed to prevent adverse outcomes in diabetic patients. Increasing intake of vitamin D by diet, oral supplements and sun exposure may be easy and cost-effective methods to improve metabolic control and prevent diabetes.

Keyword

Vitamin D; Diabetes; 25-hydroxyvitamin D; Vitamin D supplement

MeSH Terms

Diet
Hemoglobins
Humans
Hyperglycemia
Insulin Resistance
Solar System
Vitamin D
Vitamins
Hemoglobins
Vitamin D
Vitamins

Figure

• 

  Fig. 1. Vitamin D metabolism. Ca, calcium; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D; PTH, parathyroid hormone.

Reference

1. Zhang R, Naughton DP. Vitamin D in health and disease: current perspectives. Nutr J. 2010; 9:65.

2. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011; 86:50–60.

3. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92:2017–29.

4. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008; 93:512–7.

5. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001; 358:1500–3.

6. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007; 30:980–6.

7. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87:1080S–6S.

8. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010; 85:752–7.

9. Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 2009; 169:626–32.

10. Thacher TD, Fischer PR, Strand MA, Pettifor JM. Nutritional rickets around the world: causes and future directions. Ann Trop Paediatr. 2006; 26:1–16.

11. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357:266–81.

12. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006; 84:18–28.

13. The Korean Nutrition Society. Dietary reference intakes for Koreans. First revision. Seoul: Hanareum Plannling;2010.

14. Ministry for Health, Welfare and Family Affairs & Korean Centers for Disease Controls and Prevention. Korea Health Statistics 2009 - Korea National Health and Nutrition Examination Survey(KNHANES Ⅳ-3). 2010. 64. 526.

15. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008; 51:1391–8.

16. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006; 29:650–6.

17. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin Dsufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005; 135:317–22.

18. Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGrath JJ, Norman AW, Scragg R, Whiting SJ, Willett WC, Zittermann A. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr. 2007; 85:649–50.

19. Choi YM, Lee JH, Han JS. Effects of vitamin d and calcium intervention on the improvement of resistance in patients with type 2 diabetes mellitus. Korean Diabetes J. 2009; 33:324–34.