J Clin Neurol.  2007 Sep;3(3):154-157. 10.3988/jcn.2007.3.3.154.

A Case of Propofol-Induced Delayed-Onset Refractory Myoclonic Seizures

• Jeon HW
• Kang JH
• Kim HS
• Jo HY
• Kim SH

• KMID: 2135495
• DOI: http://doi.org/10.3988/jcn.2007.3.3.154

Abstract

Propofol, a GABA-mediated inhibitor of excitatory neurotransmitter, is a popular intravenous agent for general anesthesia and sedation. Its side effects reportedly include opisthotonus, seizures, and myoclonus, and are usually manageable. We present a patient who developed propofol-induced delayed-onset refractory myoclonic seizures that resisted antiepileptic drugs.

Keyword

Propofol; Myoclonic seizure; Status epilepticus

MeSH Terms

Anesthesia, General
Anticonvulsants
Humans
Myoclonus
Neurotransmitter Agents
Propofol
Seizures*
Status Epilepticus
Anticonvulsants
Neurotransmitter Agents
Propofol

Figure

• 

  Figure 1 Example EEGs showing frequent generalized polyspike-and-wave complexes followed by rhythmic fast waves at 15 Hz.

• 

  Figure 2 Example EEGs showing polyspike-and-wave complexes without rhythmic fast activity.

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