Infect Chemother.  2005 Dec;37(6):345-349.

Antibacterial Effect of Lidocaine, Thrombin, and Epinephrine

Affiliations
  • 1Division of Respiratory Diseases, Division of Infectious Diseases, College of Medicine, The Catholic University of Korea, Seoul, Korea. medkjw@catholic.ac.kr
  • 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 3Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

BACKGROUND
We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures.
MATERIALS AND METHODS
The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. RESULT: MIC50 and MIC90 of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 microgram/mL and that for K. pneumoniae were 10,000 microgram/mL. MIC50 and MIC90 of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC50 and MIC90 of epinephrine for K. pneumoniae and S. pneumoniae were above 500 microgram/mL; that for S. aureus and P. aeruginosa were 500 microgram/mL.
CONCLUSION
We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

Keyword

Lidocaine; Thrombin; Epinephrine; Antibacterial effect

MeSH Terms

Bronchoscopy
Epinephrine*
Hemostasis
Klebsiella pneumoniae
Lidocaine*
Pneumonia
Pseudomonas aeruginosa
Staphylococcus aureus
Streptococcus pneumoniae
Thrombin*
Epinephrine
Lidocaine
Thrombin
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