Endocrinol Metab.  2012 Mar;27(1):39-44. 10.3803/EnM.2012.27.1.39.

Association of Coronary Artery Disease and Osteoporotic Vertebral Fracture in Korean Men and Women

• Song SO
• Park KW
• Yoo SH
• Koh WJ
• Kang BS
• Kim TH
• Kim HJ
• Cho YH
• Cho DK
• Kim SH

• KMID: 2134816
• DOI: http://doi.org/10.3803/EnM.2012.27.1.39

Abstract

BACKGROUND
The association of osteoporotic vertebral fracture or osteoporosis with coronary artery disease (CAD) was investigated in Korean men and women.
METHODS
Four hundred consecutive postmenopausal women and men aged 50 years and older, undergoing coronary angiography, were enrolled for the evaluation of established or suspected coronary artery disease. CAD was diagnosed if there was narrowing of > 50% diameter in one or more major coronary artery. Morphometric vertebral fracture was assessed using lateral thoracic and lumbar spine radiographs. Bone mineral density was performed using dual-energy x-ray absorptiometry.
RESULTS
Of the 400 subjects in the study (mean age of 61.9 +/- 11.6 years), 256 patients had CAD. Vertebral fracture was observed in 94 (23.5%) patients. There was no difference in vertebral fracture according to the presence or absence of CAD. In logistic regression analysis, vertebral fracture was not significantly associated with CAD after adjustment for multiple risk factors. Although women had lower BMD at any given site than men, BMD was not associated with the presence or absence of CAD among 191 patients.
CONCLUSION
Our study demonstrated that osteoporotic vertebral fracture or osteoporosis was not associated with coronary artery disease in Korean men and women.

Keyword

Atherosclerosis; Bone mineral density; Coronary artery disease; Osteoporosis; Vertebral fracture

MeSH Terms

Aged
Atherosclerosis
Bone Density
Coronary Angiography
Coronary Artery Disease
Coronary Vessels
Female
Humans
Logistic Models
Male
Osteoporosis
Risk Factors
Spine

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